Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins

被引：41

作者：

Gigon, Lea ^{[1
]}

Yousefi, Shida ^{[1
]}

Karaulov, Alexander ^{[2
]}

Simon, Hans-Uwe ^{[1
,2
]}

机构：

[1] Univ Bern, Inst Pharmacol, Bern, Switzerland

[2] Sechenov Univ, Dept Clin Immunol & Allergol, Moscow, Russia

来源：

ALLERGOLOGY INTERNATIONAL | 2021年 / 70卷 / 01期

关键词：

Cytotoxicity; Eosinophil; Granule protein; Innate immunity; Neutrophil; PERMEABILITY-INCREASING PROTEIN; EXTRACELLULAR DNA TRAPS; MYELOPEROXIDASE-DERIVED OXIDANTS; GELATINASE-ASSOCIATED LIPOCALIN; MEMBRANE INTERACTION MECHANISM; ANTIMICROBIAL PEPTIDE LL-37; NECROSIS-FACTOR-ALPHA; MAJOR BASIC-PROTEIN; SCHISTOSOMA-MANSONI; CATIONIC PROTEIN;

D O I：

10.1016/j.alit.2020.11.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：30 / 38

页数：9

共 168 条

[1]

ABRAHAMSON M, 1991, BIOMED BIOCHIM ACTA, V50, P587

[2]

Ackerman S.J., 1994, EOSINOPHILS ALLERGY, P21

[3] COMPARATIVE TOXICITY OF PURIFIED HUMAN EOSINOPHIL GRANULE CATIONIC PROTEINS FOR SCHISTOSOMULA OF SCHISTOSOMA-MANSONI [J].