Copper-Catalyzed Oxidative Trifunctionalization of Olefins: An Access to Functionalized β-Keto Thiosulfones

被引：55
作者：
Huang, Shuai [1 ]
Thirupathi, Nuligonda [1 ]
Tung, Chen-Ho [1 ]
Xu, Zhenghu [1 ,2 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Colloid & Interface Chem, 27 South Shanda Rd, Jinan 250100, Shandong, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 16期
关键词：
SULFENYLATED CARBONYL-COMPOUNDS; ALPHA-OXYGENATED KETONES; C-H FUNCTIONALIZATION; ONE-POT SYNTHESIS; AEROBIC OXYSULFONYLATION; MOLECULAR-OXYGEN; BOND FORMATION; SULFUR BOND; ALKENES; EFFICIENT;
D O I：
10.1021/acs.joc.8b01161
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aerobic oxidative trifunctionalization of olefins for the synthesis of functionalized beta-keto thiosulfones has been described. The transformation proceeds through molecular oxygen activation under copper catalysis and forms the two new C-S bonds in a single operation using mild conditions. A novel Cu-catalyzed sulfonyl radical addition/oxidation/funtionalization relay mechanism was proposed for the discovered reaction.
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收藏
页码：9449 / 9455
页数：7
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