Low serum vitamin D-status, air pollution and obesity: A dangerous liaison

被引:69
作者
Barrea, Luigi [1 ]
Savastano, Silvia [2 ]
Di Somma, Carolina [3 ]
Savanelli, Maria Cristina [1 ]
Nappi, Francesca [1 ]
Albanese, Lidia [2 ]
Orio, Francesco [4 ]
Colao, Annamaria [2 ]
机构
[1] IOS & COLEMAN Srl, I-80011 Naples, Italy
[2] Federico IIUniv, Unit Endocrinol, Dipartimento Med Clin & Chirurg, Med Sch Naples, Via Sergio Pansini 5, I-80131 Naples, Italy
[3] IRCCS SDN, Napoli Via Gianturco 113, I-80143 Naples, Italy
[4] Parthenope Univ Naples, Dept Sports Sci & Wellness, Naples, Italy
关键词
Environmental factor; Vitamin D; Air pollution; Obesity; Nutritionist; D DEFICIENCY; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; D SUPPLEMENTATION; RISK; HEALTH; CHILDREN; EXPOSURE; METAANALYSIS; SUNLIGHT;
D O I
10.1007/s11154-016-9388-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of this review is to provide a general overview of the possible associations among the vitamin D status, air pollution and obesity. Sunlight exposure accounts in humans for more than 90 % of the production of vitamin D. Among emerging factors influencing sunlight-induced synthesis of vitamin D, prospective and observational studies proved that air pollution constitutes an independent risk factor in the pathogenesis of vitamin D hypovitaminosis. In addition, environmental pollutants can affect risk of obesity when inhaled, in combination with unhealthy diet and lifestyle. In turn, obesity is closely associated with a low vitamin D status and many possible mechanisms have been proposed to explain this association. The associations of air pollution with low vitamin D status on the hand and with obesity on the other hand, could provide a rationale for considering obesity as a further link between air pollution and low vitamin D status. In this respect, a vicious cycle could operate among low vitamin D status, air pollution, and obesity, with additive detrimental effects on cardio-metabolic risk in obese individuals. Besides vitamin D supplementation, nutrient combination, used to maximize the protective effects against air pollution, might also contribute to improve the vitamin D status by attenuating the "obesogen" effects of air pollution.
引用
收藏
页码:207 / 214
页数:8
相关论文
共 75 条
[1]   The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India [J].
Agarwal, KS ;
Mughal, MZ ;
Upadhyay, P ;
Berry, JL ;
Mawer, EB ;
Puliyel, JM .
ARCHIVES OF DISEASE IN CHILDHOOD, 2002, 87 (02) :111-113
[2]   The Impact of Living in Rural and Urban Areas: Vitamin D and Medical Costs in Veterans [J].
Bailey, Beth A. ;
Manning, Todd ;
Peiris, Alan N. .
JOURNAL OF RURAL HEALTH, 2012, 28 (04) :356-363
[3]   Gestational Exposure to Urban Air Pollution Related to a Decrease in Cord Blood Vitamin D Levels [J].
Baiz, Nour ;
Dargent-Molina, Patricia ;
Wark, John D. ;
Souberbielle, Jean-Claude ;
Slama, Remy ;
Annesi-Maesano, Isabella .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (11) :4087-4095
[4]   Low vitamin D status despite abundant sun exposure [J].
Binkley, N. ;
Novotny, R. ;
Krueger, D. ;
Kawahara, T. ;
Daida, Y. G. ;
Lensmeyer, G. ;
Hollis, B. W. ;
Drezner, M. K. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (06) :2130-2135
[5]   An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification [J].
Black, Lucinda J. ;
Seamans, Kelly M. ;
Cashman, Kevin D. ;
Kiely, Mairead .
JOURNAL OF NUTRITION, 2012, 142 (06) :1102-1108
[6]   Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance The Air Pollution and Cardiometabolic Disease Study [J].
Brook, Robert D. ;
Sun, Zhichao ;
Brook, Jeffrey R. ;
Zhao, Xiaoyi ;
Ruan, Yanping ;
Yan, Jianhua ;
Mukherjee, Bhramar ;
Rao, Xiaoquan ;
Duan, Fengkui ;
Sun, Lixian ;
Liang, Ruijuan ;
Lian, Hui ;
Zhang, Shuyang ;
Fang, Quan ;
Gu, Dongfeng ;
Sun, Qinghua ;
Fan, Zhongjie ;
Rajagopalan, Sanjay .
HYPERTENSION, 2016, 67 (01) :77-85
[7]  
Calderón-Garcidueñas L, 2008, INHAL TOXICOL, V20, P499, DOI [10.1080/08958370701864797, 10.1080/08958370701864797 ]
[8]   Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2.5 and ozone. APOE 4 females are at highest risk in Mexico City [J].
Calderon-Garciduenas, Lilian ;
Jewells, Valerie ;
Galaz-Montoya, Carolina ;
van Zundert, Brigitte ;
Perez-Calatayud, Angel ;
Ascencio-Ferrel, Eric ;
Valencia-Salazar, Gildardo ;
Sandoval-Cano, Marcela ;
Carlos, Esperanza ;
Solorio, Edelmira ;
Acuna-Ayala, Hilda ;
Torres-Jardon, Ricardo ;
D'Angiulli, Amedeo .
ENVIRONMENTAL RESEARCH, 2016, 150 :411-422
[9]   Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease [J].
Calderon-Garciduenas, Lilian ;
Franco-Lira, Maricela ;
D'Angiulli, Amedeo ;
Rodriguez-Diaz, Joel ;
Blaurock-Busch, Eleonore ;
Busch, Yvette ;
Chao, Chih-kai ;
Thompson, Charles ;
Mukherjee, Partha S. ;
Torres-Jardon, Ricardo ;
Perry, George .
ENVIRONMENTAL RESEARCH, 2015, 140 :579-592
[10]   EXPOSURE TO URBAN AIR POLLUTION AND BONE HEALTH IN CLINICALLY HEALTHY SIX-YEAR-OLD-CHILDREN [J].
Calderon-Garciduenas, Lilian ;
Mora-Tiscareno, Antonieta ;
Franco-Lira, Maricela ;
Torres-Jardon, Ricardo ;
Pena-Cruz, Bernardo ;
Palacios-Lopez, Carolina ;
Zhu, Hongtu ;
Kong, Linglong ;
Mendoza-Mendoza, Nicolas ;
Montesinos-Correa, Hortencia ;
Romero, Lina ;
Valencia-Salazar, Gildardo ;
Kavanaugh, Michael ;
Frenk, Silvestre .
ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, 2013, 64 (01) :23-34