Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo

被引：11

作者：

Wang, Guosong ^{[1
]}

Chen, Ruiqi ^{[1
]}

Huang, Pengfei ^{[1
]}

Hong, Junping ^{[1
]}

Cao, Jiali ^{[1
]}

Wu, Qian ^{[1
]}

Zheng, Wei ^{[1
]}

Lin, Lina ^{[1
]}

Han, Qiangyuan ^{[1
]}

Chen, Yixin ^{[1
]}

Xia, Ningshao ^{[1
]}

机构：

[1] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, State Key Lab Mol Vaccinol & Mol Diagnost, Sch Publ Hlth,Sch Life Sci, Xiamen 361102, Fujian, Peoples R China

来源：

ANTIVIRAL RESEARCH | 2021年 / 186卷

基金：

中国国家自然科学基金;

关键词：

Pseudorabies virus; Small molecule drug; Adefovir dipivoxil; ELISPOT; Therapeutic activity; ANTIVIRAL ACTIVITY; INFECTION; PRV;

D O I：

10.1016/j.antiviral.2021.105014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since 2011, highly pathogenic pseudorabies virus (PRV) variants that emerged on many farms in China have posed major economic burdens to the animal industry and have even recently caused several human cases of viral encephalitis. Currently, there are no approved effective drugs to treat PRV associated diseases in humans or pigs. Thus, it is important to develop a new effective drug for the treatment of PRV infection. To this end, we established a novel rapid method to screen drugs against PRV from 1818 kinds of small molecular drugs approved by the FDA. Using this method, we identified 21 kinds of them that can strongly suppress the proliferation of PRV. Mitoxantrone, puromycin dihydrochloride, mitoxantrone hydrochloride and adefovir dipivoxil effectively inhibited PRV in vitro. Of them, only adefovir dipivoxil could potently protect mice against lethal PRV infection. Our work identifies several kinds of potential therapeutics against PRV and may offer important guidance for controlling PRV epidemics and treating associated diseases in humans and animals.

引用

页数：9

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