Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 Findings From the Global Burden of Disease 2013 Study

被引:444
作者
Kyu, Hmwe H. [1 ]
Pinho, Christine [1 ]
Wagner, Joseph A. [1 ]
Brown, Jonathan C. [1 ]
Bertozzi-Villa, Amelia [1 ]
Charlson, Fiona J. [1 ,2 ,3 ]
Coffeng, Luc Edgar [1 ,4 ]
Dandona, Lalit [1 ,5 ]
Erskine, Holly E. [1 ,2 ,3 ]
Ferrari, Alize J. [1 ,2 ,3 ]
Fitzmaurice, Christina [1 ,6 ,7 ]
Fleming, Thomas D. [1 ]
Forouzanfar, Mohammad H. [1 ]
Graetz, Nicholas [1 ]
Guinovart, Caterina [1 ]
Haagsma, Juanita [1 ,4 ]
Higashi, Hideki [1 ]
Kassebaum, Nicholas J. [1 ,8 ]
Larson, Heidi J. [1 ,9 ]
Lim, Stephen S. [1 ]
Mokdad, Ali H. [1 ]
Moradi-Lakeh, Maziar [1 ,10 ]
Odell, Shaun V. [11 ,12 ,13 ]
Roth, Gregory A. [1 ]
Serina, Peter T. [1 ]
Stanaway, Jeffrey D. [1 ]
Misganaw, Awoke [1 ]
Whiteford, Harvey A. [1 ,2 ,3 ]
Wolock, Timothy M. [1 ]
Hanson, Sarah Wulf [1 ]
Abd-Allah, Foad [14 ]
Abera, Semaw Ferede [15 ,16 ]
Abu-Raddad, Laith J. [17 ]
AlBuhairan, Fadia S. [18 ,19 ]
Amare, Azmeraw T. [20 ,21 ,22 ]
Antonio, Carl Abelardo T. [23 ]
Artaman, Al
Barker-Collo, Suzanne L. [24 ]
Barrero, Lope H. [25 ]
Benjet, Corina [26 ]
Bensenor, Isabela M. [27 ]
Bhutta, Zulfiqar A. [28 ,29 ]
Bikbov, Boris [30 ,31 ]
Brazinova, Alexandra [32 ,33 ]
Campos-Nonato, Ismael [34 ,35 ]
Castaneda-Orjuela, Carlos A. [36 ,37 ]
Catala-Lopez, Ferran [38 ,39 ]
Chowdhury, Rajiv [40 ]
Cooper, Cyrus [41 ,42 ,43 ,44 ]
Crump, John A. [45 ]
机构
[1] Univ Washington, Inst Hlth Metr & Evaluat, 2301 Fifth Ave,Ste 600, Seattle, WA 98121 USA
[2] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia
[3] Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia
[4] Univ Med Ctr Rotterdam, Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands
[5] Publ Hlth Fdn India, New Delhi, India
[6] Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA
[7] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
[8] Seattle Childrens Hosp, Dept Anesthesiol & Pain Med, Seattle, WA USA
[9] London Sch Hyg & Trop Med, Dept Infect Dis Epidemiol, London WC1, England
[10] Iran Univ Med Sci, Dept Community Med, Tehran, Iran
[11] Univ Washington, Med Ctr, Seattle, WA 98195 USA
[12] Seattle Childrens Hosp, Seattle, WA USA
[13] Intermt Healthcare, Salt Lake City, UT USA
[14] Cairo Univ, Dept Neurol, Cairo, Egypt
[15] Kilte Awlaelo Hlth & Demog Surveillance Site, Mekelle, Ethiopia
[16] Mekelle Univ, Coll Hlth Sci, Sch Publ Hlth, Mekelle, Ethiopia
[17] Weill Cornell Med Coll Qatar, Infect Dis Epidemiol Grp, Doha, Qatar
[18] King Saud bin Abdulaziz Univ Hlth Sci, King Abdullah Specialized Childrens Hosp, Riyadh, Saudi Arabia
[19] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia
[20] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands
[21] Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia
[22] Univ Adelaide, Sch Med, Discipline Psychiat, Adelaide, SA, Australia
[23] Univ Philippines, Coll Publ Hlth, Dept Hlth Policy & Adm, Manila, Philippines
[24] Univ Auckland, Sch Psychol, Auckland 1, New Zealand
[25] Pontificia Univ Javeriana, Sch Engn, Dept Ind Engn, Bogota, Colombia
[26] Natl Inst Psychiat Ramon de la Fuente, Mexico City, DF, Mexico
[27] Univ Sao Paulo, Sao Paulo, Brazil
[28] Aga Khan Univ, Med Ctr, Karachi, Pakistan
[29] Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada
[30] AI Evdokimov Moscow State Univ Med & Dent, Moscow, Russia
[31] Academician VI Shumakov Fed Res Ctr Transplantol, Moscow, Russia
[32] Int Neurotrama Res Org, Vienna, Austria
[33] Trnava Univ, Fac Hlth Sci & Social Work, Trnava, Slovakia
[34] Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico
[35] Harvard Univ, Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA
[36] Inst Nacl Salud, Colombian Natl Hlth Observ, Bogota, Colombia
[37] Univ Nacl Colombia, Dept Publ Hlth, Epidemiol & Publ Hlth Evaluat Grp, Bogota, Colombia
[38] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada
[39] Univ Valencia, Dept Med, CIBERSAM, INCLIVA, Valencia, Spain
[40] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England
[41] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, England
[42] Univ Southampton, Natl Inst Hlth Res, Biomed Res Ctr, Southampton, England
[43] Univ Hosp Southampton Natl Hlth Serv Fdn Trust, Southampton, England
[44] Univ Oxford, Biomed Res Ctr, Natl Inst Hlth Res Musculoskeletal, Oxford, England
[45] Univ Otago, Dunedin Sch Med, Ctr Int Hlth, Dunedin, New Zealand
[46] Univ New S Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia
[47] Univ Colorado, Sch Med, Aurora, CO USA
[48] Colorado Sch Publ Hlth, Aurora, CO USA
[49] Univ Peradeniya, Fac Med, Dept Community Med, Peradeniya, Sri Lanka
[50] Dept Hlth, Off Tech Serv, Manila, Philippines
基金
英国惠康基金; 美国国家卫生研究院;
关键词
SYSTEMATIC ANALYSIS; HIV; DISABILITY; PREVALENCE; MORTALITY; SUICIDE; TIME;
D O I
10.1001/jamapediatrics.2015.4276
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
IMPORTANCE The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged < 5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14 244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35 620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905 059 deaths; 95% UI, 810304-998 125), diarrheal diseases among older children (38 325 deaths; 95% UI, 30 365-47 678), and road injuries among adolescents (115 186 deaths; 95% UI, 105 185-124 870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world's deaths from neonatal encephalopathy. Half of the world's diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. CONCLUSIONS AND RELEVANCE Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.
引用
收藏
页码:267 / 287
页数:21
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