Persistent Spiking Activity Underlies Working Memory

被引：175

作者：

Constantinidis, Christos ^{[1
]}

Funahashi, Shintaro ^{[2
,3
]}

Lee, Daeyeol ^{[4
,5
,6
,7
]}

Murray, John D. ^{[5
]}

Qi, Xue-Lian ^{[1
]}

Wang, Min ^{[4
]}

Arnsten, Amy F. T. ^{[4
]}

机构：

[1] Wake Forest Sch Med, Dept Neurobiol & Anat, Med Ctr Blvd, Winston Salem, NC 27157 USA

[2] Kyoto Univ, Kokoro Res Ctr, Yoshida Sakyo Ku, Kyoto 6068501, Japan

[3] Beijing Inst Technol, Beijing 100081, Peoples R China

[4] Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA

[5] Yale Sch Med, Dept Psychiat, New Haven, CT 06511 USA

[6] Yale Sch Med, Kavli Inst Neurosci, New Haven, CT 06510 USA

[7] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

来源：

JOURNAL OF NEUROSCIENCE | 2018年 / 38卷 / 32期

基金：

美国国家卫生研究院;

关键词：

working memory; prefrontal cortex; delay period; neurophysiology; monkey; PRIMATE PREFRONTAL CORTEX; SHORT-TERM-MEMORY; MEDIAL TEMPORAL-LOBE; NEURONAL-ACTIVITY; FRONTAL-CORTEX; DECISION-MAKING; NEURAL ACTIVITY; SUSTAINED ACTIVITY; MIXED SELECTIVITY; EXECUTIVE CONTROL;

D O I：

10.1523/JNEUROSCI.2486-17.2018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Persistent activity generated in the PFC during the delay period of working memory tasks represents information about stimuli held in memory and determines working memory performance. Alternative models of working memory, depending on the rhythmicity of discharges or exclusively on short-term synaptic plasticity, are inconsistent with the neurophysiological data.

引用

页码：7020 / 7028

页数：9

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