LncRNA LINC01116 Promotes Cancer Cell Proliferation, Migration And Invasion In Gastric Cancer By Positively Interacting With lncRNA CASC11

被引：26
作者：
Su, Xiaohui [1 ]
Zhang, Jianjun [1 ]
Luo, Xianfeng [1 ]
Yang, Wei [1 ]
Liu, Yanqing [1 ]
Liu, Yang [1 ]
Shan, Zexing [1 ]
机构：
[1] China Med Univ, Liaoning Canc Hosp & Inst, Dept Gastr Surg, Canc Hosp, 44 Xiaoheyan Rd, Shenyang 110042, Liaoning, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2019年 / 12卷
关键词：
gastric cancer; lncRNA LINC01116; lncRNA CASC11; LONG NONCODING RNAS; METASTASIS; EXPRESSION; DIAGNOSIS; MIR-145;
D O I：
10.2147/OTT.S208133
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Purpose: The oncogenic roles of lncRNA LINC01116 have been reported in several types of cancer, while its involvement in gastric cancer is unknown. This study aimed to investigate the involvement of LINC01116 in gastric cancer. Methods: Gene expression was detected by qPCR. Correlations were analyzed by linear regression. Overexpression and siRNA silencing techniques were used to analyze gene functions. Cell invasion and migration were analyzed by Transwell assays. Results: LINC01116 and lncRNA CASC11 were both upregulated in cancer tissues compared to cancer-adjacent tissues. Expression levels of LINC01116 and CASC11 were increased with the increase in clinical stages. Expression levels of LINC01116 and CASC11 were positively correlated. Overexpression of LINC01116 mediated the upregulated CASC11 in gastric cancer cells, and CASC11 overexpression also led to overexpressed LINC01116. Overexpression of LINC01116 and CASC11 led to promoted invasion and migration of gastric cancer cells. Rescue experiments showed that CASC11 knockdown attenuated the effects of LINC01116 overexpression. Overexpression of LINC01116 failed to significantly affect cancer cell proliferation. Conclusion: LINC01116 promoted cancer cell invasion and migration in gastric cancer by positively interacting with CASC11.
引用
收藏
页码：8117 / 8123
页数：7
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