Sesquiterpene isocyanides, isothiocyanates, thiocyanates, and formamides from the Thai sponge Halichondria sp.

被引：15

作者：

Prawat, Hunsa ^{[1
]}

Mahidol, Chulabhorn ^{[1
,2
]}

Kaweetripob, Wirongrong ^{[1
]}

Prachyawarakorn, Vilailak ^{[1
]}

Tuntiwachwuttikul, Pittaya ^{[3
]}

Ruchirawat, Somsak ^{[1
,2
]}

机构：

[1] Chulabhorn Res Inst, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand

[2] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol EHT, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand

[3] Phuket Rajabhat Univ, Fac Sci & Technol, Lab Nat Prod Chem, Phuket 83000, Thailand

来源：

TETRAHEDRON | 2016年 / 72卷 / 29期

关键词：

Sesquiterpenes; Isocyanides; Isothiocyanates; Thiocyanates; Formamides; Thai sponge; Halichondria; NITROGENOUS SESQUITERPENES; AXINYSSA-APLYSINOIDES; TERPENOID ISOCYANIDE; COLORIMETRIC ASSAY; COOCCURRENCE; METABOLITES;

D O I：

10.1016/j.tet.2016.05.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nine new nitrogenous sesquiterpenes (1-9) were isolated together with 11 known compounds (10-20) from the Thai marine sponge Halichondria sp. The structures of the isolated compounds were determined on the basis of extensive NMR studies and high-resolution MS measurements as well as comparison with literature data. Sixteen of these metabolites were evaluated for cytotoxic activity against six tumor cell lines. (C) 2016 Published by Elsevier Ltd.

引用

页码：4222 / 4229

页数：8

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