COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome

被引：14

作者：

Shashi, Vandana ^{[1
,2
]}

Howard, Timothy D. ^{[2
]}

Keshavan, Matcheri S. ^{[3
]}

Kaczorowski, Jessica ^{[3
]}

Berry, Margaret N. ^{[2
]}

Schoch, Kelly ^{[1
]}

Spence, Edward J. ^{[5
]}

Kwapil, Thomas R. ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pediat, Div Med Genet, Durham, NC 27710 USA

[2] Wake Forest Univ Hlth Sci, Med Genet Sect, Dept Pediat, Winston Salem, NC USA

[3] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[4] Univ N Carolina, Dept Psychol, Greensboro, NC 27412 USA

[5] Carolinas Med Ctr, Dept Pediat, Charlotte, NC 28203 USA

来源：

PSYCHIATRY RESEARCH | 2010年 / 178卷 / 02期

关键词：

Velocardiofacial syndrome; COMT Val/Met; Psychopathology; CATECHOL-O-METHYLTRANSFERASE; CARDIO-FACIAL SYNDROME; GENE POLYMORPHISM; SCHIZOPHRENIA; GENOTYPE; BRAIN; ASSOCIATION; ADOLESCENTS; PERFORMANCE; PROFILE;

D O I：

10.1016/j.psychres.2010.04.048

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：433 / 436

页数：4

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