Quinolactacins A, B and C:: Novel quinolone compounds from Penicillium sp EPF-6 I.: Taxonomy, production, isolation and biological properties

被引：41

作者：

Kakinuma, N

Iwai, H

Takahashi, S

Hamano, K

Yanagisawa, T

Nagai, K

Tanaka, K

Suzuki, K

Kirikae, F

Kirikae, T

Nakagawa, A

机构：

[1] Teikyo Univ, Dept Biosci, Utsunomiya, Tochigi 3208551, Japan

[2] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Fuchu, Tokyo 1838509, Japan

[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Labs, Itabashi Ku, Tokyo 1748511, Japan

[4] Japan Res Inst, Int Med Ctr, Shinjuku Ku, Tokyo, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 11期

关键词：

D O I：

10.7164/antibiotics.53.1247

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp, from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against turner necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).

引用

页码：1247 / 1251

页数：5

共 13 条

[1] THE ROLE OF CACHECTIN/TNF IN ENDOTOXIC-SHOCK AND CACHEXIA [J].