Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response

被引：36

作者：

Dantuma, Nico P. ^{[1
]}

Acs, Klara ^{[1
]}

Luijsterburg, Martijn S. ^{[2
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

[2] Leiden Univ, Med Ctr, Dept Human Genet, NL-2333 ZC Leiden, Netherlands

来源：

EXPERIMENTAL CELL RESEARCH | 2014年 / 329卷 / 01期

基金：

瑞典研究理事会;

关键词：

DNA repair; DNA damage response; Ubiquitin; Proteasome Protein degradation; Valosin-containing protein VCP; Cdc48; DOUBLE-STRAND BREAKS; NUCLEOTIDE EXCISION-REPAIR; RNA-POLYMERASE-II; VALOSIN-CONTAINING PROTEIN; UBIQUITIN LIGASE; INDUCED UBIQUITYLATION; TRANSLESION SYNTHESIS; 53BP1; RECRUITMENT; CDT1; DESTRUCTION; DVC1; C1ORF124;

D O I：

10.1016/j.yexcr.2014.08.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ordered assembly of DNA repair factors on chromatin has been studied in great detail, whereas we are only beginning to realize that selective extraction of proteins from chromatin plays a central role in the DNA damage response. Interestingly, the protein modifier ubiquitin not only regulates the well-documented recruitment of repair proteins, but also governs the temporally and spatially controlled extraction of proteins from DNA lesions. The facilitator of protein extraction is the ubiquitin-dependent ATPase valosin-containing protein (VCP)/p97 complex, which, through its segregase activity, directly extracts ubiquitylated proteins from chromatin. In this review, we summarize recent studies that uncovered this important role of VCP/p97 in the cellular response to genomic insults and discuss how ubiquitin regulates two intuitively counteracting activities at sites of DNA damage. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：9 / 17

页数：9

共 61 条

[1] The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks [J].

Acs, Klara ;

Luijsterburg, Martijn S. ;

Ackermann, Leena ;

Salomons, Florian A. ;

Hoppe, Thorsten ;

Dantuma, Nico P. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (12) :1345-U55

[2] Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1 [J].

Anindya, Roy ;

Ayguen, Ozan ;

Svejstrup, Jesper Q. .

MOLECULAR CELL, 2007, 28 (03) :386-397

[3] PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication [J].

Arias, EE ;

Walter, JC .

NATURE CELL BIOLOGY, 2006, 8 (01) :84-U33

[4] UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation [J].

Bandau, Susanne ;

Knebel, Axel ;

Gage, Zoe O. ;

Wood, Nicola T. ;

Alexandru, Gabriela .

BMC BIOLOGY, 2012, 10

[5] The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks [J].

Bekker-Jensen, Simon ;

Mailand, Niels .

FEBS LETTERS, 2011, 585 (18) :2914-2919

[6] Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction [J].

Bergink, Steven ;

Ammon, Tim ;

Kern, Maximilian ;

Schermelleh, Lothar ;

Leonhardt, Heinrich ;

Jentsch, Stefan .

NATURE CELL BIOLOGY, 2013, 15 (05) :526-+

[7] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].

Bienko, M ;

Green, CM ;

Crosetto, N ;

Rudolf, F ;

Zapart, G ;

Coull, B ;

Kannouche, P ;

Wider, G ;

Peter, M ;

Lehmann, AR ;

Hofmann, K ;

Dikic, I .

SCIENCE, 2005, 310 (5755) :1821-1824

[8] Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function [J].

Buchan, J. Ross ;

Kolaitis, Regina-Maria ;

Taylor, J. Paul ;

Parker, Roy .

CELL, 2013, 153 (07) :1461-1474

[9] Spartan/C1orf124, a Reader of PCNA Ubiquitylation and a Regulator of UV-Induced DNA Damage Response [J].

Centore, Richard C. ;

Yazinski, Stephanie A. ;

Tse, Alice ;

Zou, Lee .

MOLECULAR CELL, 2012, 46 (05) :625-635

[10] Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin [J].

Dantuma, Nico P. ;

Hoppe, Thorsten .

TRENDS IN CELL BIOLOGY, 2012, 22 (09) :483-491

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