Indium-promoted preparation of substituted α-methylene-γ-lactones from 2-(bromomethyl)acrylic acid and carbonyl compounds

被引：43
作者：
Choudhury, PK [1 ]
Foubelo, F [1 ]
Yus, M [1 ]
机构：
[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期
关键词：
D O I：
10.1016/S0040-4039(98)00554-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of 2-(bromomethyl)acrylic acid (1) with different carbonyl compounds (2) [CH2O, (E)-CH3CH=CHCHO, (PrCHO)-C-i, (BuCHO)-C-t, PhCHO, CH3(CH2)(5)CHO, c-C6H11CHO, Ph2CHCHO, (CH2)(5)CO] and indium powder in a 1:1 THF:H2O mixture at room temperature affords, after acidic work-up with hydrochloric acid, the corresponding alpha-methylene-gamma-butyrolactones 3. (C) 1998 Elsevier Science Ltd, All nights reserved.
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页码：3581 / 3584
页数：4
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