Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

被引：1121

作者：

Palikaras, Konstantinos ^{[1
,2
]}

Lionaki, Eirini ^{[1
]}

Tavernarakis, Nektarios ^{[1
,2
]}

机构：

[1] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Iraklion, Crete, Greece

[2] Univ Crete, Dept Basic Sci, Fac Med, Iraklion, Crete, Greece

来源：

NATURE CELL BIOLOGY | 2018年 / 20卷 / 09期

基金：

欧洲研究理事会;

关键词：

LIFE-SPAN EXTENSION; MITOCHONDRIAL-FUNCTION; FUNCTIONAL IMPAIRMENT; REGULATES MITOPHAGY; SELECTIVE AUTOPHAGY; MEDIATES MITOPHAGY; FISSION MACHINERY; UBIQUITIN CHAINS; SHARED FEATURE; PARKIN;

D O I：

10.1038/s41556-018-0176-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy metabolism. In this Review, we survey recent advances towards elucidating the molecular mechanisms that mediate mitochondrial elimination and the signalling pathways that govern mitophagy. We consider the contributions of mitophagy in physiological and pathological contexts and discuss emerging findings, highlighting the potential value of mitophagy modulation in therapeutic intervention.

引用

页码：1013 / 1022

页数：10

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