Simple and convenient synthesis of tertiary benzanilides using dichlorotriphenylphosphorane

被引：75

作者：

Azumaya, I ^{[1
]}

Okamoto, T ^{[1
]}

Imabeppu, F ^{[1
]}

Takayanagi, H ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Tokyo 1088641, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 13期

关键词：

tertiary amide; aromatic amide; coupling reagent; cyclic amide;

D O I：

10.1016/S0040-4020(03)00235-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various tertiary benzanilide derivatives were effectively synthesized from substituted benzoic acid and N-monoalkylated aniline using dichlorotriphenylphosphorane in chloroform. Yields were generally high, even when an electron-withdrawing group substituted the aromatic ring of aniline, or when an electron-donating group substituted the aromatic ring of benzoic acid. Allyl, Boc, MPM and the Z group were unaffected under these conditions. (C) 2003 Published by Elsevier Science Ltd.

引用

页码：2325 / 2331

页数：7

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