Relation of Cardiovascular Risk Factors to Right Ventricular Structure and Function as Determined by Magnetic Resonance Imaging (Results from the Multi-Ethnic Study of Atherosclerosis)

被引：56

作者：

Chahal, Harjit ^{[1
]}

Johnson, Craig ^{[3
]}

Tandri, Harikrishna ^{[2
]}

Jain, Aditya ^{[1
]}

Hundley, W. Gregory ^{[4
]}

Barr, R. Graham ^{[5
]}

Kawut, Steven M. ^{[6
]}

Lima, Joao A. C. ^{[2
]}

Bluemke, David A. ^{[1
,2
,7
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USA

[3] Univ Washington, Collaborat Hlth Studies Coordinating Ctr, Seattle, WA 98195 USA

[4] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Cardiol Sect, Winston Salem, NC 27103 USA

[5] Columbia Univ, Dept Med & Epidemiol, Med Ctr, New York, NY USA

[6] Univ Penn, Dept Med & Epidemiol, Philadelphia, PA 19104 USA

[7] NIH, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2010年 / 106卷 / 01期

关键词：

PULMONARY HEMODYNAMICS; CARDIAC-HYPERTROPHY; CIGARETTE-SMOKING; SYSTOLIC FUNCTION; GRADIENT-ECHO; HUMAN-HEART; MASS; HYPERTENSION; GENDER; VOLUME;

D O I：

10.1016/j.amjcard.2010.02.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of cardiovascular risk factors on the left ventricle is well known but their effect on right ventricle has not been studied using advanced imaging techniques. The purpose of the present study was to determine the relation between the cardiovascular risk factors and right ventricular (RV) structure and function and its interaction with the left ventricle. Cardiac magnetic resonance images from 4,204 participants free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis were analyzed. Multivariate linear regression models were used to study the cross-sectional association between individual RV parameters and risk factors. All RV parameters, except for ejection fraction, decreased with age (p <0.0001). The RV mass was positively associated with systolic blood pressure (+0.4 g, p <0.0001) and high-density lipoprotein cholesterol (+0.2 g, p <0.0001). It was inversely related with diastolic blood pressure (-0.3 g, p <0.0001) and total cholesterol (-0.2 g, p <0.01). The RV end-diastolic volume was positively associated with systolic blood pressure (+1.6 ml, p <0.01) and high-density lipoprotein cholesterol (+1.8 ml, p <0.0001). It was inversely related with diastolic blood pressure (-2.2 ml, p <0.01), total cholesterol (-1.4 ml, p <0.0001), current smoking (-2.7 ml, p <0.05), and diabetes mellitus (-3.1 ml, p <0.01). The RV ejection fraction was positively associated with systolic blood pressure (+1.0%, p <0.0001), high-density lipoprotein cholesterol (+0.4%, p <0.0001) and inversely with diastolic blood pressure (-0.7%, p <0.0001). In conclusion, the mass and volumes of the right ventricle decrease with age. Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;106:110-116)

引用

页码：110 / 116

页数：7

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