Studying pharmaceutical tablets mixing process inside a perforated pan-coater using in-line terahertz sensing

被引：0

作者：

Li, Xiaoran ^{[1
]}

Bawuah, Prince ^{[2
]}

Williams, Bryan M. ^{[3
]}

Zeitler, J. Axel ^{[2
]}

Lin, Hungyen ^{[1
]}

机构：

[1] Univ Lancaster, Dept Engn, Lancaster, England

[2] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England

[3] Univ Lancaster, Dept Comp & Commun, Lancaster, England

来源：

2020 45TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ) | 2020年

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1109/IRMMW-THZ46771.2020.9370477

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In-line terahertz sensing has been demonstrated to measure the coating thickness of individual pharmaceutical tablets during coating operation. As coating uniformity is highly dependent on tablet mixing, this study presents our research progress to date on using in-line terahertz sensing to investigate the effects of baffle design, drum rotational speed and batch size, on tablet mixing inside a laboratory-sized perforated pan coater.

引用

页数：2

共 4 条

[1] Studying pharmaceutical tablet coating process with real-time terahertz in-line sensing
Lin, Hungyen
May, Robert K.
Evans, Michael J.
Zhong, Shuncong
Warr, Ian
Gladden, Lynn F.
Shen, Yaochun
Zeitler, J. Axel
2013 38TH INTERNATIONAL CONFERENCE ON INFRARED, MILLIMETER, AND TERAHERTZ WAVES (IRMMW-THZ), 2013,
[2] Measurement of the Intertablet Coating Uniformity of a Pharmaceutical Pan Coating Process With Combined Terahertz and Optical Coherence Tomography In-Line Sensing
Lin, Hungyen
Dong, Yue
Markl, Daniel
Williams, Bryan M.
Zheng, Yalin
Shen, Yaochun
Zeitler, J. Axel
JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (04) : 1075 - 1084
[3] A quantitative comparison of in-line coating thickness distributions obtained from a pharmaceutical tablet mixing process using discrete element method and terahertz pulsed imaging
Pei, Chunlei
Lin, Hungyen
Markl, Daniel
Shen, Yao-Chun
Zeitler, J. Axel
Elliott, James A.
CHEMICAL ENGINEERING SCIENCE, 2018, 192 : 34 - 45
[4] Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy
Van Renterghem, Jeroen
Kumar, Ashish
Vervaet, Chris
Remon, Jean Paul
Nopens, Ingmar
Vander Heyden, Yvan
De Beer, Thomas
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 517 (1-2) : 119 - 127

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