A hyaluronidase/ATP tandem stimuli-responsive supramolecular assembly

被引：14
作者：
Gao, Jie [1 ]
Yu, Huijuan [2 ]
Chen, Fang-Yuan [1 ]
Hu, Xin-Yue [1 ]
Wang, Yuefei [2 ]
Guo, Dong-Sheng [1 ]
机构：
[1] Nankai Univ, Coll Chem, State Key Lab Elementoorgan Chem, Key Lab Funct Polymer Mat,Minist Educ, Tianjin 300071, Peoples R China
[2] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 301617, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 95期
关键词：
D O I：
10.1039/c9cc08199b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We designed a tandem stimuli-responsive assembly based on a guanidinium-modified calix[5]arene (GC5A-6C) and eosin Y modified hyaluronic acid (EY-HA), which showed hyaluronidase-triggered disassembly and ATP-activated release of EY. Both hyaluronidase and ATP are tumor biomarkers, and therefore, the present system shows potential in precision delivery with respect to tumor phototheranostics.
引用
收藏
页码：14387 / 14390
页数：4
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