Metabolic crossroads of iron and copper

被引：254
作者：
Collins, James F. [1 ]
Prohaska, Joseph R. [2 ]
Knutson, Mitchell D. [1 ]
机构：
[1] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA
[2] Univ Minnesota, Dept Biochem & Mol Biol, Med Sch Duluth, Duluth, MN 55812 USA
来源：
NUTRITION REVIEWS | 2010年 / 68卷 / 03期
关键词：
anemia; ceruloplasmin; copper; hephaestin; iron; INHERITED NEURODEGENERATIVE DISEASE; DIVALENT METAL TRANSPORTER-1; BLOOD-CSF BARRIER; DEFICIENT RATS; DIETARY IRON; BRAIN IRON; BRUSH-BORDER; HEREDITARY HEMOCHROMATOSIS; INTESTINAL EPITHELIUM; BASOLATERAL MEMBRANE;
D O I：
10.1111/j.1753-4887.2010.00271.x
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Interactions between the essential dietary metals, iron and copper, have been known for many years. This review highlights recent advances in iron-copper interactions with a focus on tissues and cell types important for regulating whole-body iron and copper homeostasis. Cells that mediate dietary assimilation (enterocytes) and storage and distribution (hepatocytes) of iron and copper are considered, along with the principal users (erythroid cells) and recyclers of red cell iron (reticuloendothelial macrophages). Interactions between iron and copper in the brain are also discussed. Many unanswered questions regarding the role of these metals and their interactions in health and disease emerge from this synopsis, highlighting extensive future research opportunities. (C) 2010 International Life Sciences Institute
引用
收藏
页码：133 / 147
页数：15
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