Metabolic crossroads of iron and copper

被引：264

作者：

Collins, James F. ^{[1
]}

Prohaska, Joseph R. ^{[2
]}

Knutson, Mitchell D. ^{[1
]}

机构：

[1] Univ Florida, Dept Food Sci & Human Nutr, Gainesville, FL 32611 USA

[2] Univ Minnesota, Dept Biochem & Mol Biol, Med Sch Duluth, Duluth, MN 55812 USA

来源：

NUTRITION REVIEWS | 2010年 / 68卷 / 03期

关键词：

anemia; ceruloplasmin; copper; hephaestin; iron; INHERITED NEURODEGENERATIVE DISEASE; DIVALENT METAL TRANSPORTER-1; BLOOD-CSF BARRIER; DEFICIENT RATS; DIETARY IRON; BRAIN IRON; BRUSH-BORDER; HEREDITARY HEMOCHROMATOSIS; INTESTINAL EPITHELIUM; BASOLATERAL MEMBRANE;

D O I：

10.1111/j.1753-4887.2010.00271.x

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Interactions between the essential dietary metals, iron and copper, have been known for many years. This review highlights recent advances in iron-copper interactions with a focus on tissues and cell types important for regulating whole-body iron and copper homeostasis. Cells that mediate dietary assimilation (enterocytes) and storage and distribution (hepatocytes) of iron and copper are considered, along with the principal users (erythroid cells) and recyclers of red cell iron (reticuloendothelial macrophages). Interactions between iron and copper in the brain are also discussed. Many unanswered questions regarding the role of these metals and their interactions in health and disease emerge from this synopsis, highlighting extensive future research opportunities. (C) 2010 International Life Sciences Institute

引用

页码：133 / 147

页数：15

共 136 条

[1] Effect of dietary copper deficiency on iron metabolism in the pregnant rat [J].

Andersen, Henriette S. ;

Gambling, Lorraine ;

Holtrop, Grietje ;

McArdle, Harry J. .

BRITISH JOURNAL OF NUTRITION, 2007, 97 (02) :239-246

[2]

[Anonymous], What We Eat in America (WWEIA) Database

[3] DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells [J].

Arredondo, M ;

Muñoz, P ;

Mura, CV ;

Núñez, MT .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 284 (06) :C1525-C1530

[4] Why Iron Deficiency Is Important in Infant Development [J].

Beard, John L. .

JOURNAL OF NUTRITION, 2008, 138 (12) :2534-2536

[5] Human frataxin:: iron and ferrochelatase binding surface [J].

Bencze, Krisztina Z. ;

Yoon, Taejin ;

Millan-Pacheco, Cesar ;

Bradley, Patrick B. ;

Pastor, Nina ;

Cowan, J. A. ;

Stemmler, Timothy L. .

CHEMICAL COMMUNICATIONS, 2007, (18) :1798-1800

[6] Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities [J].

Bressler, Joseph P. ;

Olivi, Luisa ;

Cheong, Jae Hoon ;

Kim, Yongbae ;

Maerten, Alex ;

Bannon, Desmond .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2007, 26 (03) :221-229

[7] Regulation of the profile of iron-management proteins in brain microvasculature [J].

Burdo, JR ;

Simpson, IA ;

Menzies, S ;

Beard, J ;

Connor, JR .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (01) :67-74

[8] TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway [J].

Calzolari, Alessia ;

Raggi, Carla ;

Deaglio, Silvia ;

Sposi, Nadia Maria ;

Stafsnes, Marit ;

Fecchi, Katia ;

Parolini, Isabella ;

Malavasi, Fabio ;

Peschle, Cesare ;

Sargiacomo, Massimo ;

Testa, Ugo .

JOURNAL OF CELL SCIENCE, 2006, 119 (21) :4486-4498

[9] The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase [J].

Casareno, RLB ;

Waggoner, D ;

Gitlin, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :23625-23628

[10] Decreased hephaestin activity in the intestine of copper-deficient mice causes systemic iron deficiency [J].

Chen, HJ ;

Huang, G ;

Su, T ;

Gao, H ;

Attieh, ZK ;

McKie, AT ;

Anderson, GJ ;

Vulpe, CD .

JOURNAL OF NUTRITION, 2006, 136 (05) :1236-1241

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