Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases

被引：47

作者：

Reddish, Florence N. ^{[1
]}

Miller, Cassandra L. ^{[1
]}

Gorkhali, Rakshya ^{[1
]}

Yang, Jenny J. ^{[1
]}

机构：

[1] Georgia State Univ, Dept Chem, CDT, Atlanta, GA 30303 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期

基金：

美国国家卫生研究院;

关键词：

calcium signaling; endoplasmic reticulum; sarcoplasmic reticulum; RyR; IP3R; SERCA pump; JP45; calsequestrin; GECI; ENCODED CA2+ INDICATORS; ENDOPLASMIC-RETICULUM; SARCOPLASMIC-RETICULUM; SKELETAL-MUSCLE; MALIGNANT-HYPERTHERMIA; INTRACELLULAR CALCIUM; ALZHEIMERS-DISEASE; RELEASE CHANNEL; FLUORESCENT INDICATORS; INOSITOL 1,4,5-TRISPHOSPHATE;

D O I：

10.3390/ijms18051024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The flow of intracellular calcium (Ca2+) is critical for the activation and regulation of important biological events that are required in living organisms. As the major Ca2+ repositories inside the cell, the endoplasmic reticulum (ER) and the sarcoplasmic reticulum (SR) of muscle cells are central in maintaining and amplifying the intracellular Ca2+ signal. The morphology of these organelles, along with the distribution of key calcium-binding proteins (CaBPs), regulatory proteins, pumps, and receptors fundamentally impact the local and global differences in Ca2+ release kinetics. In this review, we will discuss the structural and morphological differences between the ER and SR and how they influence localized Ca2+ release, related diseases, and the need for targeted genetically encoded calcium indicators (GECIs) to study these events.

引用

页数：21

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