Erythrocyte invasion and functionally inhibitory antibodies in Plasmodium falciparum malaria

被引：11

作者：

Persson, Kristina E. M. ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17177 Stockholm, Sweden

来源：

ACTA TROPICA | 2010年 / 114卷 / 03期

关键词：

Malaria; Antibodies; Immunity; Invasion; Inhibition; MEROZOITE SURFACE PROTEIN-1; APICAL MEMBRANE ANTIGEN-1; C-TERMINAL FRAGMENT; BINDING ANTIGEN; PARASITE GROWTH; IN-VITRO; PHENOTYPIC VARIATION; MONOCLONAL-ANTIBODY; VACCINE CANDIDATE; CRYSTAL-STRUCTURE;

D O I：

10.1016/j.actatropica.2009.05.017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Malaria is a disease that kills several million people every year. P. falciparum merozoites invade new erythrocytes every 48 h, causing fever, anemia and cerebral malaria. Effective immunity against malaria develops slowly and only after repeated exposure. Antibodies are an important part of this immunity. However, the antigens that mediate immunity by inducing functionally imperative antibodies have not yet been identified. This review gives an overview of the erythrocyte invasion process, which has been described to include several different antigens. Invasion inhibitory antibodies can inhibit merozoite penetration of new erythrocytes, and different methods for measurement of the presence of functionally important antibodies have been employed. ELISA. Invasion inhibition assays and ADCI are some of the methods discussed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：138 / 143

页数：6

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