In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine

被引：166
作者：
Domarle, O
Blampain, G
Agnaniet, H
Nzadiyabi, T
Lebibi, J
Brocard, J
Maciejewski, L
Biot, C
Georges, AJ
Millet, P
机构：
[1] CIRMF, Unite Parasitol Med, Franceville, Gabon
[2] Univ Sci & Tech Masuku, Franceville, Gabon
[3] Univ Sci & Tech Lille Flandres Artois, Lille, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 03期
关键词：
D O I：
10.1128/AAC.42.3.540
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.
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页码：540 / 544
页数：5
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