Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications†

被引：12
作者：
Baptista, Ana Catarina [1 ]
Brito, Miguel [1 ]
Marques, Ana [1 ]
Ferreira, Isabel [1 ]
机构：
[1] Univ Nova Lisboa, FCT, Fac Ciencias & Tecnol, CENIMAT I3N,Dept Ciencia Mat, Campus Caparica, P-2829516 Lisbon, Portugal
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2021年 / 9卷 / 16期
基金：
欧盟地平线“2020”;
关键词：
DELIVERY; SYSTEMS; PATCH;
D O I：
10.1039/d1tb00249j
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Electronic controlled drug release from fibres was studied using ibuprofen as a model drug, one of the most popular analgesics, to impregnate gauze and cellulose acetate (CA) membranes. Conductivity in the range of 1-10 mS cm(-1) was obtained in polypyrrole (Ppy) functionalised gauze and CA fibres, providing voltage-controlled drug release in a system consisting of Ppy/Ibuprofen/Ppy membranes and an Ag electrode. SEM images evidenced the Ppy adhesion to fibres and Micro Raman spectra proved drug incorporation and release. A small wound adhesive built with these membranes retains ibuprofen at 1.5 V and quickly releases it when -0.5 V is applied.
引用
收藏
页码：3515 / 3522
页数：8
相关论文
共 22 条
[1]   Conducting-polymer nanotubes for controlled drug release [J].
Abidian, MR ;
Kim, DH ;
Martin, DC .
ADVANCED MATERIALS, 2006, 18 (04) :405-+
[2]   Recent Advances in Wearable Transdermal Delivery Systems [J].
Amjadi, Morteza ;
Sheykhansari, Sahar ;
Nelson, Bradley J. ;
Sitti, Metin .
ADVANCED MATERIALS, 2018, 30 (07)
[3]   Dermal Patch with Integrated Flexible Heater for on Demand Drug Delivery [J].
Bagherifard, Sara ;
Tamayol, Ali ;
Mostafalu, Pooria ;
Akbari, Mohsen ;
Comotto, Mattia ;
Annabi, Nasim ;
Ghaderi, Masoumeh ;
Sonkusale, Sameer ;
Dokmeci, Mehmet R. ;
Khademhosseini, Ali .
ADVANCED HEALTHCARE MATERIALS, 2016, 5 (01) :175-184
[4]   Cellulose-based electrospun fibers functionalized with polypyrrole and polyaniline for fully organic batteries [J].
Baptista, A. C. ;
Ropio, I. ;
Romba, B. ;
Nobre, J. P. ;
Henriques, C. ;
Silva, J. C. ;
Martins, J. I. ;
Borges, J. P. ;
Ferreira, I. .
JOURNAL OF MATERIALS CHEMISTRY A, 2018, 6 (01) :256-265
[5]  
Cho, 2007, FORENSIC SCI J, V1, P55
[6]  
CSANYI E, 2016, INT J NANOMED, P1201, DOI DOI 10.2147/IJN.S99198
[7]   Hierarchical nanostructured polypyrrole/graphene composites as supercapacitor electrode [J].
Fan, Xin ;
Yang, Zhewei ;
He, Nan .
RSC ADVANCES, 2015, 5 (20) :15096-15102
[8]   A Stretchable and Flexible Cardiac Tissue-Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation [J].
Feiner, Ron ;
Wertheim, Lior ;
Gazit, Danielle ;
Kalish, Or ;
Mishal, Gal ;
Shapira, Assaf ;
Dvir, Tal .
SMALL, 2019, 15 (14)
[9]   Stimuli-responsive bio-based polymeric systems and their applications [J].
Gao, Shuting ;
Tang, Guosheng ;
Hua, Dawei ;
Xiong, Ranhua ;
Han, Jingquan ;
Jiang, Shaohua ;
Zhang, Qilu ;
Huang, Chaobo .
JOURNAL OF MATERIALS CHEMISTRY B, 2019, 7 (05) :709-729
[10]   Conjugated polymers as robust carriers for controlled delivery of anti-inflammatory drugs [J].
Krukiewicz, Katarzyna ;
Zak, Jerzy K. .
JOURNAL OF MATERIALS SCIENCE, 2014, 49 (16) :5738-5745
123