New immortalized cell lines of patients with small supernumerary marker chromosome:: Towards the establishment of a cell bank

被引：10

作者：

Toennies, Holger

Pietrzak, Joanna

Bocian, Ewa

MacDermont, Kay

Kuechler, Alma

Belitz, Britta

Trautmann, Udo

Schmidt, Angela

Schulze, Berndt

Rodriguez, Laura

Bill, Franz

Yardin, Catharine

Kosyakova, Nadezda

Volleth, Marianne

Mkrtchyan, Hasmik

Schreyer, Isolde

von Eggeling, Ferdinand

Weise, Anja

Mrasek, Kristin

Liehr, Thomas

机构：

[1] Inst Human Genet & Anthropol, D-07743 Jena, Germany

[2] Free Univ Berlin, Inst Human Genet, D-1000 Berlin, Germany

[3] Inst Mother & Child Hlth, Dept Med Genet, Warsaw, Poland

[4] N W London Hosp, NHS Trust, Harrow, Middx, England

[5] Univ Clin Jena, Dept Pediat, Jena, Germany

[6] Practice Human Genet, Berlin, Germany

[7] Univ Erlangen Nurnberg, Inst Human Genet, D-8520 Erlangen, Germany

[8] Pracitce Human Genet, Hannover, Germany

[9] Minist Sanidad & Consumo, Estudio Colaborat Espanol Malformac Congenitas, Ctr Invest Anomalias Congenitas, Inst Salud Carlos III, Madrid, Spain

[10] MCL Med Labs, Niederwangen, Switzerland

[11] Serv Histol Cytol Cytogenet Biol Cell & Reprod, Limoges, France

[12] Med Genet Res Ctr, Moscow, Russia

[13] Inst Human Genet, Magdeburg, Germany

[14] State Univ, Dept Genet, Jerewan, Armenia

[15] State Univ, Lab Cytogenet, Jerewan, Armenia

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2007年 / 55卷 / 06期

关键词：

small supernumerary marker chromosome; cell line; Epstein-Barr virus immortalization; genotype-phenotype correlation; cell bank;

D O I：

10.1369/jhc.6A7161.2007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sixteen newly established cell lines with small supernumerary marker chromosomes (sSMC) derived from chromosomes 1, 2, 4, 6, 7, 8, 14, 15, 16, 18, 19, 21, and 22 are reported. Two sSMC are neocentric and derived from 15q24.1-qter and 2q35-q36, respectively. Two further cases each present with two sSMC of different chromosomal origin. sSMC were characterized by multicolor fluorescence in situ hybridization for their chromosomal origin and genetic content. Moreover, uniparental disomy of the sister chromosomes of the sSMC was excluded in all nine cases studied for that reason. The 16 cases provide information to establish a refined genotype-phenotype correlation of sSMC and are available for future studies.

引用

页码：651 / 660

页数：10

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