Pseudoephedrine-Benefits and Risks

被引:38
作者
Glowacka, Krystyna [1 ]
Wiela-Hojenska, Anna [1 ]
机构
[1] Wroclaw Med Univ, Dept Clin Pharmacol, Borowska 211a St, PL-50556 Wroclaw, Poland
关键词
pseudoephedrine; sympathomimetic; adverse reactions; non-medical use; EPHEDRINE; PHARMACOKINETICS; STEREOCHEMISTRY; METHCATHINONE; PERFORMANCE; EXPOSURE; UPDATE; USERS;
D O I
10.3390/ijms22105146
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pseudoephedrine (PSE) is a drug with a long history of medical use; it is helpful in treating symptoms of the common cold and flu, sinusitis, asthma, and bronchitis. Due to its central nervous system (CNS) stimulant properties and structural similarity to amphetamine, it is also used for non-medical purposes. The substance is taken as an appetite reducer, an agent which eliminates drowsiness and fatigue, to improve concentration and as a doping agent. Due to its easier availability, it is sometimes used as a substitute for amphetamine or methamphetamine. Pseudoephedrine is also a substrate (precursor) used in the production of these drugs. Time will tell whether legal restrictions on the sale of this drug will reduce the scale of the problem associated with its misuse.
引用
收藏
页数:11
相关论文
共 43 条
[31]   Stereochemistry of ephedrine and its environmental significance: Exposure and effects directed approach [J].
Rice, Jack ;
Proctor, Kathryn ;
Lopardo, Luigi ;
Evans, Sian ;
Kasprzyk-Hordern, Barbara .
JOURNAL OF HAZARDOUS MATERIALS, 2018, 348 :39-46
[32]   Effect of oral pseudoephedrine on blood pressure and heart rate - A meta-analysis [J].
Salerno, SM ;
Jackson, JL ;
Berbano, EP .
ARCHIVES OF INTERNAL MEDICINE, 2005, 165 (15) :1686-1694
[33]   The role of pseudoephedrine on daytime somnolence in patients suffering from perennial allergic rhinitis (PAR) [J].
Sherkat, Amir A. ;
Sardana, Niti ;
Safaee, Sahar ;
Lehman, Erik B. ;
Craig, Timothy J. .
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2011, 106 (02) :97-102
[34]   Manganese-Induced Parkinsonism due to Ephedrone Abuse [J].
Sikk, Katrin ;
Haldre, Sulev ;
Aquilonius, Sten-Magnus ;
Taba, Pille .
PARKINSONS DISEASE, 2011, 2011
[35]  
Sobczak L, 2018, FARM POL, V74, P199, DOI [10.32383/farmpol/119176, DOI 10.32383/FARMPOL/119176]
[36]   A Parkinsonian syndrome in methcathinone users and the role of manganese [J].
Stepens, Ainars ;
Logina, Inara ;
Liguts, Viesturs ;
Aldins, Pauls ;
Eksteina, Ilze ;
Platkajis, Ardis ;
Martinsone, Inese ;
Terauds, Elmars ;
Rozentale, Baiba ;
Donaghy, Michael .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (10) :1009-1017
[37]   ANALYSIS OF THE PHENOMENON OF OVER-THE-COUNTER DRUG ABUSE AND NOT CONTROLLED HERBS TRADE BY POLISH ADOLESCENTS: PART I [J].
Suchecka, Daria ;
Kucharska-Mazur, Jolanta ;
Groszewska, Katarzyna ;
Mak, Monika ;
Samochowiec, Jerzy ;
Samochowiec, Agnieszka .
MEDYCYNA PRACY, 2017, 68 (03) :413-422
[38]  
Szumny D., 2007, DENT MED PROBL, V44, P507
[39]   Influences of Urinary pH on the Pharmacokinetics of Three Amphetamine-Type Stimulants Using a New High-Performance Liquid Chromatographic Method [J].
Wang, Ling ;
Feng, Fang ;
Wang, Xue Quan ;
Zhu, Lan .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (02) :728-738
[40]   Reinforcing effect of pseudoephedrine isomers and the mechanism of action [J].
Wee, S ;
Ordway, GA ;
Woolverton, WL .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 493 (1-3) :117-125