Secondary acute myeloid leukemia in a child treated for retinoblastoma: A case report with review of literature

被引:2
|
作者
Sneha, Latha M. [1 ]
Arockia, John [2 ]
Suman, Febi Renjitha [3 ]
Khethan, Vikas [4 ]
机构
[1] Sri Ramachandra Inst Higher Educ & Res, Div Pediat Hemato Oncol, Chennai, Tamil Nadu, India
[2] Sri Ramachandra Inst Higher Educ & Res, Dept Pediat, Chennai, Tamil Nadu, India
[3] Sri Ramachandra Inst Higher Educ & Res, Dept Pathol, Chennai, Tamil Nadu, India
[4] Sankara Netralaya, Dept Vitreoretina & Ocular Oncol, Chennai, Tamil Nadu, India
关键词
Epipodophyllotoxins; retinoblastoma; secondary AML; CANCER;
D O I
10.4103/jfmpc.jfmpc_1538_20
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The most devastating late adverse effect of childhood cancer treatment is development of second malignancies. Retinoblastoma is the most common ocular malignancy of childhood and has a very good cure rate. Children with hereditary retinoblastoma have an increased risk of developing second malignancies due to the genetic cancer predisposition status and the additional risk factors are exposure to chemotherapy (alkylating agents and topoisomerase II inhibitors) and external beam radiotherapy during treatment. The common chemotherapy regimen of retinoblastoma consisting of etoposide, an epipodophyllotoxin is associated with risk of secondary AML (s-AML). We report a case of child with bilateral retinoblastoma who developed secondary AML after being treated for retinoblastoma.
引用
收藏
页码:5796 / 5798
页数:3
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