Generation of Photopolymerized Microparticles Based on PEGDA Using Microfluidic Devices. Part 1. Initial Gelation Time and Mechanical Properties of the Material

被引:9
作者
Acosta-Cuevas, Jose M. [1 ]
Gonzalez-Garcia, Jose [1 ]
Garcia-Ramirez, Mario [2 ]
Perez-Luna, Victor H. [3 ]
Omar Cisneros-Lopez, Erick [1 ]
Gonzalez-Nunez, Ruben [1 ]
Gonzalez-Reynoso, Orfil [1 ]
机构
[1] Univ Guadalajara, Chem Engn Dept, CUCEI, Blvd M Garcia Barragan 1451, Guadalajara 44430, Jalisco, Mexico
[2] Univ Guadalajara, Elect Dept, CUCEI, Blvd M Garcia Barragan 1451, Guadalajara 44430, Jalisco, Mexico
[3] IIT, Dept Chem & Biol Engn, 10 West 33rd St, Chicago, IL 60616 USA
关键词
PEGDA Hydrogel; photopolymerization; microfluidic devices; initial gelation time; POLY(ETHYLENE GLYCOL) DIACRYLATE; HYDROGELS; MICRODROPLETS; RELEASE;
D O I
10.3390/mi12030293
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Photopolymerized microparticles are made of biocompatible hydrogels like Polyethylene Glycol Diacrylate (PEGDA) by using microfluidic devices are a good option for encapsulation, transport and retention of biological or toxic agents. Due to the different applications of these microparticles, it is important to investigate the formulation and the mechanical properties of the material of which they are made of. Therefore, in the present study, mechanical tests were carried out to determine the swelling, drying, soluble fraction, compression, cross-linking density (M-c) and mesh size (xi) properties of different hydrogel formulations. Tests provided sufficient data to select the best formulation for the future generation of microparticles using microfluidic devices. The initial gelation times of the hydrogels formulations were estimated for their use in the photopolymerization process inside a microfluidic device. Obtained results showed a close relationship between the amount of PEGDA used in the hydrogel and its mechanical properties as well as its initial gelation time. Consequently, it is of considerable importance to know the mechanical properties of the hydrogels made in this research for their proper manipulation and application. On the other hand, the initial gelation time is crucial in photopolymerizable hydrogels and their use in continuous systems such as microfluidic devices.
引用
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页码:1 / 19
页数:19
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