Improving Effects of Narazuke Lees on Fatty Liver of Rats Induced by High-Fat and High-Cholesterol Diets

被引：0

作者：

Nakasa, Teruko ^{[1
]}

Yamagami, Sayuri ^{[1
]}

Tanaka, Toshiaki ^{[2
]}

Tanaka, Hiroko ^{[2
]}

Hariu, Hitoshi ^{[2
]}

Okinaka, Osamu ^{[1
]}

机构：

[1] Doshisha Womens Coll Liberal Arts, Fac Human Life Sci, Dept Food Sci & Nutr, Kamigyo Ku, Kyoto 6020893, Japan

[2] Tanakachou Co Ltd, Simogyo Ku, Kyoto 6008421, Japan

来源：

FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2014年 / 20卷 / 04期

关键词：

Narazuke lees; fatty liver; high-fat and high-cholesterol diet; lipid metabolism; INSULIN-RESISTANCE; BY-PRODUCTS; METABOLIC SYNDROME; SAKE LEES; DISEASE; ENZYME; ACID; STEATOHEPATITIS; EXPRESSION; INHIBITORS;

D O I：

10.3136/fstr.20.849

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

With the purpose of using Narazuke lees as a functional foods material, its effect on fatty liver of rats fed a high-fat and high-cholesterol diet was investigated. While significant accumulation of triacylglycerol was observed in the liver of rats fed high-fat and high-cholesterol diet was observed, rats fed diet supplemented with Narazuke lees showed significantly increased fecal dry weight, as well as increased fecal excretion of total lipids and total bile acids. Further, free fatty acids, glucose and insulin concentrations in the blood were significantly decreased, and amelioration of insulin resistance was observed. In the liver, reduction of FAS activity, significant increase in CPT-Ia activity and promotion of fatty acid beta-oxidation were observed. An improving effect on fatty liver was observed by the suppression of lipid accumulation. The amount of liver TBARS was significantly reduced, indicating the inhibition of NASH progression.

引用

页码：849 / 857

页数：9

共 35 条

[1] Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet [J].

Alberdi, Goiuri ;

Rodriguez, Victor M. ;

Teresa Macarulla, M. ;

Miranda, Jonatan ;

Churruca, Itziar ;

Portillo, Maria P. .

NUTRITION, 2013, 29 (03) :562-567

[2] Effects of dietary sake cake on cholesterol metabolism in rats [J].

Ashida, Y ;

Saito, Y ;

Kawato, A ;

Suginami, K ;

Imayasu, S .

NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, 1997, 71 (02) :137-143

[3] Selective versus total insulin resistance: A pathogenic paradox [J].

Brown, Michael S. ;

Goldstein, Joseph L. .

CELL METABOLISM, 2008, 7 (02) :95-96

[4]

Chiang MT, 1998, INT J VITAM NUTR RES, V68, P328

[5] DEMONSTRATION OF 2 POPULATIONS OF CELLS IN HUMAN FEMALE HETEROZYGOUS FOR GLUCOSE-6-PHOSPHATEDEHYDROGENASE VARIANTS [J].

DAVIDSON, RG ;

NITOWSKY, HM ;

CHILDS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1963, 50 (03) :481-&

[6]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[7] The metabolic syndrome as a predictor of nonalcoholic fatty liver disease [J].

Hamaguchi, M ;

Kojima, T ;

Takeda, N ;

Nakagawa, T ;

Taniguchi, H ;

Fujii, K ;

Omatsu, T ;

Nakajima, T ;

Sarui, H ;

Shimazaki, M ;

Kato, T ;

Okuda, J ;

Ida, K .

ANNALS OF INTERNAL MEDICINE, 2005, 143 (10) :722-728

[8]

Hirahata R, 2013, J JPN SOC FOOD SCI, V60, P72, DOI 10.3136/nskkk.60.72

[9]

Izu H., 2006, J BREW SOC JAPAN, V101, P896

[10] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome [J].

Kadowaki, Takashi ;

Yamauchi, Toshimasa ;

Kubota, Naoto ;

Hara, Kazuo ;

Ueki, Kohjiro ;

Tobe, Kazuyuki .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1784-1792

← 1 2 3 4 →