Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors

被引：90

作者：

Labrosse, B

Labernardière, JL

Dam, E

Trouplin, V

Skrabal, K

Clavel, F

Mammano, F

机构：

[1] Hop Bichat Claude Bernard, Unite Rech Antivirale, INSERM, U552, F-75018 Paris, France

[2] Viralliance SAS, Paris, France

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 02期

关键词：

D O I：

10.1128/JVI.77.2.1610-1613.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 plasma viruses from 29 entry inhibitor-naive patients were characterized for their susceptibilities to T-20, AMD3100, and RANTES. A strikingly wide range of susceptibilities to T-20 was observed that was influenced by coreceptor usage but not by the susceptibilities of the viruses to inhibitors that target the chemokine receptors or by polymorphisms in the gp41 N helix.

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页码：1610 / 1613

页数：4

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