Use of Anti-Tumor Necrosis Factor Alpha Therapy in Patients with Concurrent Rheumatoid Arthritis and Hepatitis B or Hepatitis C: A Retrospective Analysis of 32 Patients

被引：27

作者：

Ballanti, Eleonora ^{[1
]}

Conigliaro, Paola ^{[1
]}

Chimenti, Maria Sole ^{[1
]}

Kroegler, Barbara ^{[1
]}

Di Muzio, Gioia ^{[1
]}

Guarino, Maria Domenica ^{[1
]}

Triggianese, Paola ^{[1
]}

Gigliucci, Gianfranco ^{[1
]}

Novelli, Lucia ^{[1
]}

Barbato, Carmen ^{[1
]}

Perricone, Roberto ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Med Sistemi, I-00133 Rome, Italy

来源：

DRUG DEVELOPMENT RESEARCH | 2014年 / 75卷

关键词：

rheumatoid arthritis; anti-TNF; hepatitis B; hepatitis C;

D O I：

10.1002/ddr.21193

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The safety of tumor necrosis factor-alpha (TNF-) inhibitors in the setting of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections is controversial. The use of anti-TNF- in rheumatoid arthritis (RA) is associated with an increased risk of hepatitis re-activation. This paper reports experience of using etanercept and adalimumab in 32 patients with RA and previous HBV or HCV infection. No cases of HBV or HCV reactivation were seen. In just over a fifth of patients, increased transaminases levels were seen, which were associated with concomitant use of disease-modifying antirheumatic drugs, isoniazid prophylaxis, or alcohol abuse. In our experience, anti-TNF- therapy appears to be safe in RA patients with previous HBV or HCV infection, but monitoring remains necessary in these patients.

引用

页码：S42 / S45

页数：4

共 3 条

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