Mitochondrial Cristae: Where Beauty Meets Functionality

被引：590

作者：

Cogliati, Sara ^{[1
]}

Enriquez, Jose A. ^{[1
,2
]}

Scorrano, Luca ^{[3
,4
]}

机构：

[1] Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain

[2] Univ Zaragoza, Dept Bioquim, Zaragoza, Spain

[3] Venetian Inst Mol Med, Dulbecco Telethon Inst, Padua, Italy

[4] Univ Padua, Dept Biol, Padua, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 03期

关键词：

STOMATIN-LIKE PROTEIN-2; DOMINANT OPTIC ATROPHY; RESPIRATORY-CHAIN; ATP SYNTHASE; SUPRAMOLECULAR ORGANIZATION; CYTOCHROME-C; COMPLEX-I; OXIDATIVE-PHOSPHORYLATION; INNER-MEMBRANE; CONTACT SITE;

D O I：

10.1016/j.tibs.2016.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.

引用

页码：261 / 273

页数：13

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