Mitochondrial Cristae: Where Beauty Meets Functionality

被引：590

作者：

Cogliati, Sara ^{[1
]}

Enriquez, Jose A. ^{[1
,2
]}

Scorrano, Luca ^{[3
,4
]}

机构：

[1] Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain

[2] Univ Zaragoza, Dept Bioquim, Zaragoza, Spain

[3] Venetian Inst Mol Med, Dulbecco Telethon Inst, Padua, Italy

[4] Univ Padua, Dept Biol, Padua, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2016年 / 41卷 / 03期

关键词：

STOMATIN-LIKE PROTEIN-2; DOMINANT OPTIC ATROPHY; RESPIRATORY-CHAIN; ATP SYNTHASE; SUPRAMOLECULAR ORGANIZATION; CYTOCHROME-C; COMPLEX-I; OXIDATIVE-PHOSPHORYLATION; INNER-MEMBRANE; CONTACT SITE;

D O I：

10.1016/j.tibs.2016.01.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial cristae are dynamic bioenergetic compartments whose shape changes under different physiological conditions. Recent discoveries have unveiled the relation between cristae shape and oxidative phosphorylation (OXPHOS) function, suggesting that membrane morphology modulates the organization and function of the OXPHOS system, with a direct impact on cellular metabolism. As a corollary, cristae-shaping proteins have emerged as potential modulators of mitochondrial bioenergetics, a concept confirmed by genetic experiments in mouse models of respiratory chain deficiency. Here, we review our knowledge of mitochondrial ultrastructural organization and how it impacts mitochondrial metabolism.

引用

页码：261 / 273

页数：13

共 107 条

[1] Cardiolipin Affects the Supramolecular Organization of ATP Synthase in Mitochondria [J].

Acehan, Devrim ;

Malhotra, Ashim ;

Xu, Yang ;

Ren, Mindong ;

Stokes, David L. ;

Schlame, Michael .

BIOPHYSICAL JOURNAL, 2011, 100 (09) :2184-2192

[2] Respiratory Active Mitochondrial Supercomplexes [J].

Acin-Perez, Rebeca ;

Fernandez-Silva, Patricio ;

Luisa Peleato, Maria ;

Perez-Martos, Acisclo ;

Enriquez, Jose Antonio .

MOLECULAR CELL, 2008, 32 (04) :529-539

[3] Defective mitochondrial fusion, altered respiratory function, and distorted cristae structure in skin fibroblasts with heterozygous OPA1 mutations [J].

Agier, Virginie ;

Oliviero, Patricia ;

Laine, Jeanne ;

L'Hermitte-Stead, Caroline ;

Girard, Samantha ;

Fillaut, Sandrine ;

Jardel, Claude ;

Bouillaud, Frederic ;

Bulteau, Anne Laure ;

Lombes, Anne .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (10) :1570-1580

[4] OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [J].

Ban, Tadato ;

Heymann, Juergen A. W. ;

Song, Zhiyin ;

Hinshaw, Jenny E. ;

Chan, David C. .

HUMAN MOLECULAR GENETICS, 2010, 19 (11) :2113-2122

[5] X-linked cardioskeletal myopathy and neutropenia (Barth syndrome) (MIM 302060) [J].

Barth, PG ;

Wanders, RJA ;

Vreken, P ;

Janssen, EAM ;

Lam, J ;

Baas, F .

JOURNAL OF INHERITED METABOLIC DISEASE, 1999, 22 (04) :555-567

[6] Cardiolipin-dependent Reconstitution of Respiratory Supercomplexes from Purified Saccharomyces cerevisiae Complexes III and IV [J].

Bazan, Soledad ;

Mileykovskaya, Eugenia ;

Mallampalli, Venkata K. P. S. ;

Heacock, Philip ;

Sparagna, Genevieve C. ;

Dowhan, William .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (01) :401-411

[7] A new non-canonical pathway of Gαq protein regulating mitochondrial dynamics and bioenergetics [J].

Beninca, Cristiane ;

Planaguma, Jesus ;

de Vreitas Shuck, Adriana ;

Acin-Perez, Rebeca ;

Pablo Munoz, Juan ;

Mateus de Almeida, Marina ;

Brown, Joan H. ;

Murphy, Anne N. ;

Zorzano, Antonio ;

Antonio Enriquez, Jose ;

Aragay, Anna M. .

CELLULAR SIGNALLING, 2014, 26 (05) :1135-1146

[8] Phosphatidylethanolamine and Cardiolipin Differentially Affect the Stability of Mitochondrial Respiratory Chain Supercomplexes [J].

Boettinger, Lena ;

Horvath, Susanne E. ;

Kleinschroth, Thomas ;

Hunte, Carola ;

Daum, Guenther ;

Pfanner, Nikolaus ;

Becker, Thomas .

JOURNAL OF MOLECULAR BIOLOGY, 2012, 423 (05) :677-686

[9] Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability [J].

Bohovych, Iryna ;

Fernandez, Mario R. ;

Rahn, Jennifer J. ;

Stackley, Krista D. ;

Bestman, Jennifer E. ;

Anandhan, Annadurai ;

Franco, Rodrigo ;

Claypool, Steven M. ;

Lewis, Robert E. ;

Chan, Sherine S. L. ;

Khalimonchuk, Oleh .

SCIENTIFIC REPORTS, 2015, 5

[10] Genetic variability of respiratory complex abundance, organization and activity in mouse brain [J].

Buck, K. J. ;

Walter, N. A. R. ;

Denmark, D. L. .

GENES BRAIN AND BEHAVIOR, 2014, 13 (02) :135-143

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