Treatment of retroperitoneal sarcoma: current standards and new developments

被引:45
作者
van Houdt, Winan J. [1 ]
Zaidi, Shane [3 ]
Messiou, Christina [4 ]
Thway, Khin [5 ]
Strauss, Dirk C. [1 ]
Jones, Robin L. [2 ]
机构
[1] Royal Marsden Hosp, Dept Surg, London, England
[2] Royal Marsden Hosp, Dept Clin Oncol, London, England
[3] Royal Marsden Hosp, Dept Radiol, London, England
[4] Royal Marsden Hosp, Dept Pathol, London, England
[5] Royal Marsden Hosp, Sarcoma Unit, Dept Med Oncol, London, England
关键词
centralization; leiomyosarcoma; liposarcoma; retroperitoneal sarcoma; SOFT-TISSUE SARCOMA; CONTROLLED PHASE-3 TRIAL; BEAM RADIATION-THERAPY; DEDIFFERENTIATED LIPOSARCOMA; CLINICAL-TRIAL; MANAGEMENT; RESECTION; RADIOTHERAPY; RECURRENCE; CHEMOTHERAPY;
D O I
10.1097/CCO.0000000000000377
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of reviewRetroperitoneal sarcomas are rare tumors and with complex treatment. In this manuscript we give an overview of current standards in treatment of this disease and discuss new developments.Recent findingsSurgery with complete resection of the primary tumor is still the only curative modality. The role of preoperative radiotherapy is not clear and is currently being investigated in a clinical trial. Neo-adjuvant chemotherapy is not the standard of care but can be considered occasionally when complete resection is uncertain. Local and distant recurrent disease carries a dismal prognosis, although long-term survival can be achieved. Liposarcomas tend to recur locally, whereas distant recurrences are more often seen in leiomyosarcoma and other subtypes. Outcome improves when patients are treated in high volume sarcoma centers. In the metastatic setting, newer systemic agents have recently been approved.SummaryTreatment of retroperitoneal sarcomas is complex and all patients should be treated in a multidisciplinary sarcoma centers. Increasing international collaboration of expert centers in sharing expertise and performing clinical trials might lead to better treatment and improved survival.
引用
收藏
页码:260 / 267
页数:8
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