Differential patterns of acquired virulence genes distinguish Salmonella strains

被引：117

作者：

Conner, CP ^{[1
]}

Heithoff, DM ^{[1
]}

Julio, SM ^{[1
]}

Sinsheimer, RL ^{[1
]}

Mahan, MJ ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 08期

关键词：

pathogenesis; horizontal transfer; in vivo expression technology; ivi; Salmonella typhimurium;

D O I：

10.1073/pnas.95.8.4641

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Analysis of several Salmonella typhimurium in vivo-induced genes located in regions of atypical base composition has uncovered acquired genetic elements that cumulatively engender pathogenicity. Many of these regions are associated with mobile elements, encode predicted adhesin and invasin-like functions, and are required for full virulence. Some of these regions distinguish broad host range from host-adapted Salmonella serovars and may contribute to inherent differences in host specificity, tissue tropism, and disease manifestation. Maintenance of this archipelago of acquired sequence by selection in specific hosts reveals a fossil record of the evolution of pathogenic species.

引用

页码：4641 / 4645

页数：5

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