Tissue Macrophages Suppress Viral Replication and Prevent Severe Immunopathology in an Interferon-I-Dependent Manner in Mice

被引：71

作者：

Lang, Philipp A. ^{[1
,2
]}

Recher, Mike ^{[1
]}

Honke, Nadine ^{[3
]}

Scheu, Stefanie ^{[4
]}

Borkens, Stephanie ^{[4
]}

Gailus, Nicole ^{[3
]}

Krings, Caroline ^{[3
]}

Meryk, Andreas ^{[3
]}

Kulawik, Andreas ^{[3
]}

Cervantes-Barragan, Luisa ^{[5
]}

Van Rooijen, Nico ^{[6
]}

Kalinke, Ulrich ^{[7
,9
]}

Ludewig, Burkhard ^{[5
]}

Hengartner, Hans ^{[1
]}

Harris, Nicola ^{[8
]}

Haeussinger, Dieter ^{[3
]}

Ohashi, Pamela S. ^{[2
]}

Zinkernagel, Rolf M. ^{[1
]}

Lang, Karl S. ^{[1
,3
]}

机构：

[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

[2] Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON M4X 1K9, Canada

[3] Univ Dusseldorf, Dept Gastroenterol Hepatol & Infectiol, D-40225 Dusseldorf, Germany

[4] Univ Dusseldorf, Inst Med Microbiol & Hosp Hyg, D-40225 Dusseldorf, Germany

[5] Kantonal Hosp, Inst Immunobiol, St Gallen, Switzerland

[6] Vrije Univ Amsterdam, Dept Mol Cell Biol, Amsterdam, Netherlands

[7] Ctr Expt & Clin Infect Res, TWINCORE, Hannover, Germany

[8] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol, Swiss Vaccine Res Inst, Global Hlth Inst, CH-1015 Lausanne, Switzerland

[9] Inst Expt Infect Res, Hannover, Germany

来源：

HEPATOLOGY | 2010年 / 52卷 / 01期

基金：

瑞士国家科学基金会; 加拿大健康研究院;

关键词：

HEPATITIS-C VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MONONUCLEAR PHAGOCYTE SYSTEM; HUMAN KUPFFER CELLS; ENDOTHELIAL-CELLS; B-VIRUS; IMMUNOHISTOCHEMICAL LOCALIZATION; DENDRITIC CELLS; HBV INFECTION; MARGINAL ZONE;

D O I：

10.1002/hep.23640

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for the efficient capture of infectious virus and for preventing viral replication. The latter process involved activation of Kupffer cells by interferon (IFN)-I and prevented viral spread to neighboring hepatocytes. In the absence of Kupffer cells, hepatocytes were not able to suppress virus replication, even in the presence of IFN-I, leading to prolonged viral replication and severe T cell-dependent immunopathology. Conclusion: Tissue-resident macrophages play a crucial role in early viral capture and represent the major liver cell type exhibiting responsiveness to IFN-I and providing control of viral replication. (HEPATOLOGY 2010;52:25-32)

引用

页码：25 / 32

页数：8

共 24 条

[1] TISSUE MACROPHAGES PREVENT SEVERE IMMUNOPATHOLOGY DUE TO IFN-I DEPENDENT VIRUS SUPPRESSION
Lang, K.
Lang, P.
Haeussinger, D.
JOURNAL OF HEPATOLOGY, 2010, 52 : S41 - S41
[2] Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection
Lee, Amanda J.
Feng, Emily
Chew, Marianne, V
Balint, Elizabeth
Poznanski, Sophie M.
Giles, Elizabeth
Zhang, Ali
Marzok, Art
Revill, Spencer D.
Vahedi, Fatemeh
Dubey, Anisha
Ayaub, Ehab
Jimenez-Saiz, Rodrigo
McGrath, Joshua J. C.
Ritchie, Tyrah M.
Jordana, Manel
Jonigk, Danny D.
Ackermann, Maximilian
Ask, Kjetil
Miller, Matthew
Richards, Carl D.
Ashkar, Ali A.
PLOS PATHOGENS, 2022, 18 (05)
[3] HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS RESTRICTS INTERFERON GAMMA RESPONSES IN MACROPHAGES IN A REPLICATION-DEPENDENT MANNER
Cline, T.
Sekar, K.
Beck, D.
CYTOKINE, 2016, 87 : 126 - 126
[4] Type I Interferon Counters or Promotes Coxiella burnetii Replication Dependent on Tissue
Hedges, Jodi F.
Robison, Amanda
Kimmel, Emily
Christensen, Kelly
Lucas, Erin
Ramstead, Andrew
Jutila, Mark A.
INFECTION AND IMMUNITY, 2016, 84 (06) : 1815 - 1825
[5] CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
Shaabani, Namir
Duhan, Vikas
Khairnar, Vishal
Gassa, Asmae
Ferrer-Tur, Rita
Haeussinger, Dieter
Recher, Mike
Zelinskyy, Gennadiy
Liu, Jia
Dittmer, Ulf
Trilling, Mirko
Scheu, Stefanie
Hardt, Cornelia
Lang, Philipp A.
Honke, Nadine
Lang, Karl S.
CELL DEATH & DISEASE, 2016, 7 : e2446 - e2446
[6] CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
Namir Shaabani
Vikas Duhan
Vishal Khairnar
Asmae Gassa
Rita Ferrer-Tur
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Mike Recher
Gennadiy Zelinskyy
Jia Liu
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Mirko Trilling
Stefanie Scheu
Cornelia Hardt
Philipp A Lang
Nadine Honke
Karl S Lang
Cell Death & Disease, 2016, 7 : e2446 - e2446
[7] RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication
Pengfei Li
Xiangle Zhang
Weijun Cao
Fan Yang
Xiaoli Du
Zhengwang Shi
Miaotao Zhang
Xiangtao Liu
Zixiang Zhu
Haixue Zheng
Virology Journal, 15
[8] RIG-I is responsible for activation of type I interferon pathway in Seneca Valley virus-infected porcine cells to suppress viral replication
Li, Pengfei
Zhang, Xiangle
Cao, Weijun
Yang, Fan
Du, Xiaoli
Shi, Zhengwang
Zhang, Miaotao
Liu, Xiangtao
Zhu, Zixiang
Zheng, Haixue
VIROLOGY JOURNAL, 2018, 15
[9] Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Ryan, Tristram A. J.
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Rehill, Aisling M.
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Cheallaigh, Cliona Ni
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Carty, Michael
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McLoughlin, Rachel M.
Wygrecka, Malgorzata
Preston, Roger J. S.
Zaslona, Zbigniew
O'Neill, Luke A. J.
NATURE COMMUNICATIONS, 2023, 14 (01)
[10] Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Tristram A. J. Ryan
Alexander Hooftman
Aisling M. Rehill
Matt D. Johansen
Eóin C. O’ Brien
Juliana E. Toller-Kawahisa
Mieszko M. Wilk
Emily A. Day
Hauke J. Weiss
Pourya Sarvari
Emilio G. Vozza
Fabian Schramm
Christian G. Peace
Alessia Zotta
Stefan Miemczyk
Christina Nalkurthi
Nicole G. Hansbro
Gavin McManus
Laura O’Doherty
Siobhan Gargan
Aideen Long
Jean Dunne
Clíona Ní Cheallaigh
Niall Conlon
Michael Carty
Padraic G. Fallon
Kingston H. G. Mills
Emma M. Creagh
James S. O’ Donnell
Paul J. Hertzog
Philip M. Hansbro
Rachel M. McLoughlin
Małgorzata Wygrecka
Roger J. S. Preston
Zbigniew Zasłona
Luke A. J. O’Neill
Nature Communications, 14 (1)

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