Recovery of long-term denervated human muscles induced by electrical stimulation

被引：125

作者：

Kern, H ^{[1
]}

Salmons, S

Mayr, W

Rossini, K

Carraro, U

机构：

[1] Wilheminenspital Wien, Ludwig Boltzmann Inst Elctrostimulat & Phys Rehab, A-1171 Vienna, Austria

[2] Univ Liverpool, Dept Human Anat & Cell Biol, Liverpool L69 3BX, Merseyside, England

[3] Univ Vienna, Dept Biomed Engn & Phys, Vienna, Austria

[4] Univ Padua, CNR, Inst Neurosci, Dept Biomed Sci, Padua, Italy

来源：

MUSCLE & NERVE | 2005年 / 31卷 / 01期

关键词：

chronic denervation; electrical stimulation; human; muscle regeneration; paraplegia;

D O I：

10.1002/mus.20149

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the restorative potential of intensive electrical stimulation in a patient with long-standing quadriceps denervation. Stimulation started 18 months after injury. After 26 months, the thighs were visibly less wasted. Muscle cross-sectional areas, measured by computerized tomography, increased from 36.0 cm(2) to 57.9 cm(2) (right) and from 36.1 cm(2) to 52.4 cm(2) (left). Knee torque had become sufficient to maintain standing without upper extremity support. Biopsies revealed evidence of both growth and regeneration of myofibers. The results suggest that electrical stimulation may offer a route to the future development of mobility aids in patients with lower motor neuron lesions.

引用

页码：98 / 101

页数：4

共 15 条

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[2]

BOONSTRA AM, 1987, SCAND J REHABIL MED, V19, P127

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