Hypothalamic-pituitary-gonadal axis involvement in learning and memory and Alzheimer's disease: more than just estrogen

被引：45

作者：

Blair, Jeffrey A. ^{[1
]}

McGee, Henry ^{[1
]}

Bhatta, Sabina ^{[1
]}

Palm, Russell ^{[2
]}

Casadesus, Gemma ^{[1
]}

机构：

[1] Kent State Univ, Dept Biol Sci, 256 Cunningham Hall, Kent, OH 44242 USA

[2] Univ Toledo, Sch Med, Toledo, OH 43606 USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2015年 / 6卷

关键词：

luteinizing hormone; menopause; ovariectomy; estrogen; testosterone; memory; Alzheimer's disease; LUTEINIZING-HORMONE RECEPTOR; RANDOMIZED CONTROLLED-TRIAL; MESSENGER-RNA EXPRESSION; CYCLING FEMALE RATS; HEALTHY CELL BIAS; MIDDLE-AGED RATS; POSTMENOPAUSAL WOMEN; COGNITIVE FUNCTION; REPLACEMENT THERAPY; GONADOTROPIN-LEVELS;

D O I：

10.3389/fendo.2015.00045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Accumulating studies affirm the effects of age-related endocrine dysfunction on cognitive decline and increasing risk of neurodegenerative diseases. It is well known that estrogens can be protective for cognitive function, and more recently androgens and luteinizing hormone have also been shown to modulate learning and memory. Understanding the mechanisms underlying hypothalamic pituitary gonadal axis-associated cognitive dysfunction is crucial for therapeutic advancement. Here, we emphasize that reproductive hormones are influential in maintaining neuronal health and enhancing signaling cascades that lead to cognitive impairment. We summarize and critically evaluate age-related changes in the endocrine system, their implications in the development of Alzheimer's disease, and the therapeutic potential of endocrine modulation in the prevention of age-related cognitive decline.

引用

页数：8

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