SARS-CoV-2 anti-spike antibody titres after vaccination with BNT162b2 in naive and previously infected individuals

被引：23

作者：

Lombardi, Andrea ^{[1
,2
]}

Consonni, Dario ^{[3
]}

Oggioni, Massimo ^{[4
]}

Bono, Patrizia ^{[4
]}

Renteria, Sara U. ^{[4
]}

Piatti, Alessandra ^{[5
]}

Pesatori, Angela C. ^{[3
,6
]}

Castaldi, Silvana ^{[7
,8
]}

Muscatello, Antonio ^{[1
]}

Riboldi, Luciano ^{[9
]}

Ceriotti, Ferruccio ^{[4
]}

Bandera, Alessandra ^{[1
,2
,10
]}

Gori, Andrea ^{[1
,2
,10
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Infect Dis Unit, Via Francesco Sforza 35, I-20122 Milan, Italy

[2] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Epidemiol Unit, Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore, Clin Lab, Milan, Italy

[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med Direct, Milan, Italy

[6] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[7] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy

[8] Univ Milan, Qual & Internal Audit Privacy Unit, Milan, Italy

[9] Fdn IRCCS Ca Granda Osped MaggiorePoliclin, Occupat Hlth Unit, Milan, Italy

[10] Univ Milan, Ctr Multidisciplinary Res Hlth Sci MACH, Milan, Italy

来源：

JOURNAL OF INFECTION AND PUBLIC HEALTH | 2021年 / 14卷 / 08期

关键词：

COVID-19; Vaccination; Healthcare workers; BNT162b2;

D O I：

10.1016/j.jiph.2021.07.005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Great expectations are placed in vaccines against COVID-19 to control the pandemic. We reviewed the antibody titres in a cohort of healthcare workers (HCWs) vaccinated with BNT162b2 to assess the influence of a previous infection on them. We stratified the results according to the individual history of nasopharyngeal swab (NPS) and symptoms. Among 3475 HCWs the highest titres were recorded among those infected more than 6 months before vaccination, independently of symptoms, followed by those infected less than 6 months before vaccination, especially in those with symptoms, and by uninfected HCWs. Vaccination with BNT162b2 can boost immunity acquired through infection, particularly in those infected more than 6 months before vaccination. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).

引用

页码：1120 / 1122

页数：3

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