Effects of aging on basement membrane-related gene expression of the skeletal muscle in rats

被引：7
|
作者：
Kanazawa, Yuji [1 ,2 ]
Nagano, Mamoru [2 ]
Koinuma, Satoshi [2 ]
Sugiyo, Shinichi [3 ]
Shigeyoshi, Yasufumi [2 ]
机构：
[1] Hokuriku Univ, Dept Med Technol & Clin Engn, Kanazawa, Ishikawa 9201180, Japan
[2] Kindai Univ, Grad Sch Med Sci, Dept Anat & Neurobiol, Ohnohigashi, Osakasayama 5898511, Japan
[3] Osaka Univ Human Sci, Dept Phys Therapy, Shojya Ku, Settsu 5668501, Japan
来源：
BIOMEDICAL RESEARCH-TOKYO | 2021年 / 42卷 / 03期
关键词：
COLLAGEN; EXERCISE; MT1-MMP; ATROPHY; CELLS;
D O I：
10.2220/biomedres.42.115
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The basement membrane (BM), with collagen IV as a major component, plays an important role in the maintenance of muscle structure and its robustness. To investigate the effects of aging on factors related to BM construction, we compared the expression status of these factors in 3- and 20-month-old male Wistar rats. The expression levels of Col4a1 and Col4a2 (encoding collagen IV), Sparc (involved in collagen IV functionalization), and Mmp14 (a collagen IV degradation factor) were decreased. These results suggest that aging suppresses collagen IV synthetic and degradative factors and affects BM-related factors in the steady state.
引用
收藏
页码：115 / 119
页数：5
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