"One-Pot" Approach to 8-Acylated 2-Quinolinones via Palladium-Catalyzed Regioselective Acylation of Quinoline N-Oxides

被引：62

作者：

Chen, Xiaopei ^{[1
]}

Cui, Xiuling ^{[1
,2
,3
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Dept Chem, Zhengzhou 450052, Peoples R China

[2] Huaqiao Univ, Inst Mol Med, Sch Biomed Sci, Xiamen Key Lab Ocean & Gene Drugs, Xiamen 361021, Fujian, Peoples R China

[3] Chinese Educ Minist, Engn Res Ctr Mol Med, Xiamen 361021, Fujian, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 10期

关键词：

C-H ALKENYLATION; DIRECT ARYLATION; C-8; POSITION; BOND FUNCTIONALIZATION; ACTIVATION; ARYL; ALDEHYDES; ALKYNES; MILD; ANNULATION;

D O I：

10.1021/acs.orglett.6b00923

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A "one-pot" facile and efficient protocol for 8-acylated 2-quinolinones has been developed through palladium-catalyzed acylation of quinoline N-oxides, which proceeds with high selectivity at the C8-position. The desired products were isolated in up to 95% yield and good functional group tolerance. A palladacycle was isolated from the catalytic process and proposed as a key intermediate.

引用

页码：2411 / 2414

页数：4

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