Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development

被引:33
作者
Xu, Siguang [1 ,2 ]
Liu, Cui [2 ]
Ma, Yana [1 ]
Ji, Hong-Long [1 ,3 ,4 ]
Li, Xiumin [2 ]
机构
[1] Xinxiang Med Univ, Inst Lung & Mol Therapy, Xinxiang 453003, Henan, Peoples R China
[2] Xinxiang Med Univ, Ctr Canc Res, Xinxiang 453003, Henan, Peoples R China
[3] Univ Texas Hlth Sci Ctr Tyler, Dept Cellular & Mol Biol, Tyler, TX 75708 USA
[4] Univ Texas Hlth Sci Ctr Tyler, Texas Lung Injury Inst, Tyler, TX 75708 USA
关键词
EPITHELIAL NA+ CHANNEL; SENSING ION CHANNELS; GAMMA-ENAC EXPRESSION; GLIOMA HYBRID-CELLS; FUNCTIONAL EXPRESSION; CATION CHANNEL; BK CHANNELS; BEWO CELLS; BETA-ENAC; MIGRATION;
D O I
10.1155/2016/2190216
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The ENaC/degenerin ion channel superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC). ENaC is a multimeric ion channel formed by heteromultimeric membrane glycoproteins, which participate in a multitude of biological processes by mediating the transport of sodium (Na+) across epithelial tissues such as the kidney, lungs, bladder, and gut. Aberrant ENaC functions contribute to several human disease states including pseudohypoaldosteronism, Liddle syndrome, cystic fibrosis, and salt-sensitive hypertension. Increasing evidence suggests that ion channels not only regulate ion homeostasis and electric signaling in excitable cells but also play important roles in cancer cell behaviors such as proliferation, apoptosis, invasion, and migration. Indeed, ENaCs/ASICs had been reported to be associated with cancer characteristics. Given their cell surface localization and pharmacology, pharmacological strategies to target ENaC/ASIC family members may be promising cancer therapeutics.
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页数:6
相关论文
共 65 条
[31]   Involvement of p38 MAPK in hypotonic stress-induced stimulation of β- and γ-ENaC expression in renal epithelium [J].
Niisato, Naomi ;
Taruno, Akiyuki ;
Marunaka, Yoshinori .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 358 (03) :819-824
[32]   Hypotonic stress upregulates β- and γ-ENaC expression through suppression of ERK by inducing MKP-1 [J].
Niisato, Naomi ;
Ohta, Mariko ;
Eaton, Douglas C. ;
Marunaka, Yoshinori .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2012, 303 (02) :F240-F252
[33]   MEMBRANE-POTENTIAL AND SODIUM FLUX IN NEUROBLASTOMA-X GLIOMA HYBRID-CELLS - EFFECTS OF AMILORIDE AND SERUM [J].
ODONNELL, ME ;
VILLEREAL, ML .
JOURNAL OF CELLULAR PHYSIOLOGY, 1982, 113 (03) :405-412
[34]  
ODONNELL ME, 1983, J PHARMACOL EXP THER, V226, P368
[35]   Opinion - How many drug targets are there? [J].
Overington, John P. ;
Al-Lazikani, Bissan ;
Hopkins, Andrew L. .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (12) :993-996
[36]   A Ca2+ signal is found upstream of cytochrome c release during apoptosis in HeLa cells [J].
Pu, YM ;
Luo, KQ ;
Chang, DC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 299 (05) :762-769
[37]   BK channels in human glioma cells [J].
Ransom, CB ;
Sontheimer, H .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :790-803
[38]   Volume-activated, chloride currents contribute to the resting conductance and invasive migration of human glioma cells [J].
Ransom, CB ;
O'Neal, JT ;
Sontheimer, H .
JOURNAL OF NEUROSCIENCE, 2001, 21 (19) :7674-7683
[39]   Ion channels in toxicology [J].
Restrepo-Angulo, Ivan ;
De Vizcaya-Ruiz, Andrea ;
Camacho, Javier .
JOURNAL OF APPLIED TOXICOLOGY, 2010, 30 (06) :497-512
[40]   Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice [J].
Rofstad, Einar K. ;
Mathiesen, Berit ;
Kindem, Kristil ;
Galappathi, Kanthi .
CANCER RESEARCH, 2006, 66 (13) :6699-6707