Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract

被引:9
作者
Cangussu da Silva, Lucia Regina [1 ]
机构
[1] Univ Salgado de Oliveira, Dept Ciencias Saude, BR-36036 Juiz De Fora, MG, Brazil
关键词
Zika virus; sexual transmission; male reproductive tract; human reproduction; VECTOR-BORNE TRANSMISSION; MALE SEXUAL TRANSMISSION; WHOLE-BLOOD; IMMUNE-RESPONSES; UNITED-STATES; GENITAL-TRACT; INFECTION; SEMEN; CELLS; RNA;
D O I
10.3390/pathogens7020051
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sexual transmission of Zika virus (ZIKV) is a matter of great concern. Infectious viral particles can be shed in semen for as long as six months after infection and can be transferred to male and female sexual partners during unprotected sexual intercourse. The virus can be found inside spermatozoa and could be directly transferred to the oocyte during fertilization. Sexual transmission of ZIKV can contribute to the rise in number of infected individuals in endemic areas as well as in countries where the mosquito vector does not thrive. There is also the possibility, as has been demonstrated in mouse models, that the vaginal deposition of ZIKV particles present in semen could lead to congenital syndrome. In this paper, we review the current literature to understand ZIKV trafficking from the bloodstream to the human male reproductive tract and viral interactions with host cells in interstitial spaces, tubule walls, annexed glands and semen. We hope to highlight gaps to be filled by future research and potential routes for vaccine and antiviral development.
引用
收藏
页数:19
相关论文
共 123 条
[1]   Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract [J].
Adefuye, Anthonio O. ;
Adeola, Henry A. ;
Sales, Kurt J. ;
Katz, Arieh A. .
JOURNAL OF IMMUNOLOGY RESEARCH, 2016, 2016
[2]   Zika virus-associated neurological disorders: a review [J].
Araujo, Abelardo Q. C. ;
Silva, Marcus Tulius T. ;
Araujo, Alexandra P. Q. C. .
BRAIN, 2016, 139 :2122-2130
[3]   Probable sexual transmission of Zika virus from a vasectomised man [J].
Arsuaga, Marta ;
Garcia Bujalance, Silvia ;
Diaz-Menendez, Marta ;
Vazquez, Ana ;
Arribas, Jose R. .
LANCET INFECTIOUS DISEASES, 2016, 16 (10) :1107-1107
[4]   Complete Genome Sequence of Zika Virus Isolated from Semen [J].
Atkinson, Barry ;
Graham, Victoria ;
Miles, Rory W. ;
Lewandowski, Kuiama ;
Dowall, Stuart D. ;
Pullan, Steven T. ;
Hewson, Roger .
GENOME ANNOUNCEMENTS, 2016, 4 (05)
[5]   Detection of Zika Virus in Semen [J].
Atkinson, Barry ;
Hearn, Pasco ;
Afrough, Babak ;
Lumley, Sarah ;
Carter, Daniel ;
Aarons, Emma J. ;
Simpson, Andrew J. ;
Brooks, Timothy J. ;
Hewson, Roger .
EMERGING INFECTIOUS DISEASES, 2016, 22 (05) :940-940
[6]   Prolonged shedding of Chikungunya virus in semen and urine: A new perspective for diagnosis and implications for transmission [J].
Bandeira, Antonio Carlos ;
Campos, Gubio Soares ;
Diniz Rocha, Veronica Franca ;
de Freitas Souza, Bruno Solano ;
Pereira Soares, Milena Botelho ;
Oliveira, Alexsandro Araujo ;
de Abreu, Yara Carvalho ;
Menezes, Gabriela Sant'Ana ;
Sardi, Silvia Ines .
IDCASES, 2016, 6 :100-103
[7]   Neonatal encephalitis due to Chikungunya vertical transmission: First report in Brazil [J].
Bandeira, Antonio Carlos ;
Campos, Gubio Soares ;
Sardi, Silvia Ines ;
Diniz Rocha, Veronica Franca ;
Mendes Rocha, Guilherme Cesar .
IDCASES, 2016, 5 :57-59
[8]   Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil [J].
Barbosa, Carla M. ;
Di Paola, Nicholas ;
Cunha, Marielton P. ;
Rodrigues-Jesus, Monica J. ;
Araujo, Danielle B. ;
Silveira, Vanessa B. ;
Leal, Fabyano B. ;
Mesquita, Flavio S. ;
Botosso, Viviane F. ;
Zanotto, Paolo M. A. ;
Durigon, Edison L. ;
Silva, Marcos V. ;
Oliveira, Danielle B. L. .
EMERGING INFECTIOUS DISEASES, 2018, 24 (01) :176-178
[9]   Probable transfusion-transmitted Zika virus in Brazil [J].
Barjas-Castro, Maria L. ;
Angerami, Rodrigo N. ;
Cunha, Mariana S. ;
Suzuki, Akemi ;
Nogueira, Juliana S. ;
Rocco, Iray M. ;
Maeda, Adriana Y. ;
Vasami, Fernanda G. S. ;
Katz, Gizelda ;
Boin, Ilka F. S. F. ;
Stucchi, Raquel S. B. ;
Resende, Mariangela R. ;
Esposito, Danillo L. A. ;
de Souza, Renato P. ;
da Fonseca, Benedito A. ;
Addas-Carvalho, Marcelo .
TRANSFUSION, 2016, 56 (07) :1684-1688
[10]   Working with Zika and Usutu Viruses In Vitro [J].
Barr, Kelli L. ;
Anderson, Benjamin D. ;
Prakoso, Dhani ;
Long, Maureen T. .
PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (08)