Microwave Absorbing Fe3O4@mTiO2 Nanoparticles as an Intelligent Drug Carrier for Microwave-Triggered Synergistic Cancer Therapy

被引：14

作者：

Peng, Hongxia ^{[1
]}

Hu, Jilin ^{[1
]}

Hu, Chuanyue ^{[1
]}

Wu, Tengyan ^{[1
]}

Tian, Xiuying ^{[1
]}

机构：

[1] Hunan Univ Humanities Sci & Technol, Hunan Prov Key Lab Fine Ceram & Powder Mat, Loudi 137400, Hunan Province, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2017年 / 17卷 / 08期

关键词：

Fe3O4@mTiO(2); Mesoporous; Magnetic; Microwave Thermal Therapy; Chemotherapy; Homogeneous Precipitation Method; ABSORPTION PROPERTIES; IRON-OXIDE; DELIVERY; SHELL; RELEASE; NANOCOMPOSITE; NANOCARRIER; ENRICHMENT; POLYMER;

D O I：

10.1166/jnn.2017.13809

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein a novel multifunctional nanoplatform based on Fe3O4@mTiO(2) (m was short for mesoporous) nanoparticles is developed for effective microwave-triggered synergistic cancer therapy. Fe3O4@mTiO(2) nanoparticles employed in the study not only function as microwave absorbing agents but also as nanocarriers with a high drug loading efficiency. Fe3O4 core confers the system biocompatibility and cells targeting ability. Moreover, mTiO(2) shell as drug carriers with a high drug loading efficiency and loading drug can controlled release on the microwave irradiation. By combining these capabilities, the multifunctional nanoparticles show an effective therapeutic efficiency toward the target cells.

引用

收藏

页码：5139 / 5146

页数：8

相关论文

共 28 条

[11]

Peng H. X., 2015, NEW J CHEM, V1460, P40

[12] Glycine-functionalized Fe3O4@TiO2:Er3+,Yb3+ nanocarrier for microwave-triggered controllable drug release and study on mechanism of loading/release process using microcalorimetry [J].

Peng, Hongxia ;

Cui, Bin ;

Zhao, Weiwei ;

Wang, Yingsai ;

Chang, Zhuguo ;

Wang, Yaoyu .

EXPERT OPINION ON DRUG DELIVERY, 2015, 12 (09) :1397-1409

[13] A multifunctional β-CD-modified Fe3O4@ZnO:Er3+,Yb3+ nanocarrier for antitumor drug delivery and microwave-triggered drug release [J].

Peng, Hongxia ;

Cui, Bin ;

Li, Guangming ;

Wang, Yingsai ;

Li, Nini ;

Chang, Zhuguo ;

Wang, Yaoyu .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 46 :253-263

[14] Microwave-induced thermoacoustic computed tomography with a clinical contrast agent of NMG2[Gd(DTPA)] [J].

Qin, Huan ;

Yang, Sihua ;

Xing, Da .

APPLIED PHYSICS LETTERS, 2012, 100 (03)

[15] A novel microwave stimulus remote controlled anticancer drug release system based on Fe3O4@ZnO@mGd2O3:Eu@P(NIPAm-co-MAA) multifunctional nanocarriers [J].

Qiu, Hongjin ;

Cui, Bin ;

Zhao, Weiwei ;

Chen, Ping ;

Peng, Hongxia ;

Wang, Yaoyu .

JOURNAL OF MATERIALS CHEMISTRY B, 2015, 3 (34) :6919-6927

[16] Novel Fe3O4@ZnO@mSiO2 Nanocarrier for Targeted Drug Delivery and Controllable Release with Microwave Irradiation [J].

Qiu, Hongjin ;

Cui, Bin ;

Li, Guangming ;

Yang, Jianhui ;

Peng, Hongxia ;

Wang, Yingsai ;

Li, Nini ;

Gao, Ruicheng ;

Chang, Zhuguo ;

Wang, Yaoyu .

JOURNAL OF PHYSICAL CHEMISTRY C, 2014, 118 (27) :14929-14937

[17] Targeted Mesoporous Iron Oxide Nanoparticles-Encapsulated Perfluorohexane and a Hydrophobic Drug for Deep Tumor Penetration and Therapy [J].

Su, Yu-Lin ;

Fang, Jen-Hung ;

Liao, Chia-Ying ;

Lin, Chein-Ting ;

Li, Yun-Ting ;

Hu, Shang-Hsiu .

THERANOSTICS, 2015, 5 (11) :1233-1248

[18] Fabrication of a novel magnetic yolk-shell Fe3O4@mTiO2@mSiO2 nanocomposite for selective enrichment of endogenous phosphopeptides from a complex sample [J].

Wan, Hao ;

Li, Jinan ;

Yu, Wenguang ;

Liu, Zheyi ;

Zhang, Quanqing ;

Zhang, Weibing ;

Zou, Hanfa .

RSC ADVANCES, 2014, 4 (86) :45804-45808

[19] Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect [J].

Wang, Chao ;

Xu, Huan ;

Liang, Chao ;

Liu, Yumeng ;

Li, Zhiwei ;

Yang, Guangbao ;

Cheng, Hang ;

Li, Yonggang ;

Liu, Zhuang .

ACS NANO, 2013, 7 (08) :6782-6795

[20] Microwave absorption properties and infrared emissivities of ordered mesoporous C-TiO2 nanocomposites with crystalline framework [J].

Wang, Tao ;

He, Jianping ;

Zhou, Jianhua ;

Tang, Jing ;

Guo, Yunxia ;

Ding, Xiaochun ;

Wu, Shichao ;

Zhao, Jianqing .

JOURNAL OF SOLID STATE CHEMISTRY, 2010, 183 (12) :2797-2804