Natural products with anti-aging potential: Affected targets and molecular mechanisms

被引：74

作者：

Catana, Cristina-Sorina ^{[1
]}

Atanasov, Atanas G. ^{[2
,3
]}

Berindan-Neagoe, Ioana ^{[4
,5
,6
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Dept Med Biochem, Cluj Napoca 400012, Romania

[2] Polish Acad Sci, Inst Genet & Anim Breeding, PL-05552 Jastrzebiec, Poland

[3] Univ Vienna, Dept Phannacognosy, Althanstr 14, A-1090 Vienna, Austria

[4] MEDFUTURE Res Ctr Adv Med, Cluj Napoca 400012, Romania

[5] Iuliu Hatieganu Univ Med & Pharm, Inst Doctoral Studies, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400012, Romania

[6] Prof Dr Ion Chiricuta Oncol Inst, Dept Expt Pathol, Cluj Napoca, Romania

来源：

BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 06期

关键词：

Aging; Caloric restriction; NF-kB; SIRT1; mTOR; AMPK1; Polyphenols; Histone modifications; Transcription; Signaling pathways; CALORIC RESTRICTION MIMETICS; BREAST-CANCER; AUTOPHAGY; RESVERATROL; SIRTUINS; THERAPY; NAD(+); SIRT1;

D O I：

10.1016/j.biotechadv.2018.03.012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In recent years, there has been a great deal of attention toward the molecular machinery relevant to age-related progression controlled through the external intervention of polyphenols- an epigenetic-modulating diet. Natural products modulate cellular longevity through histone post-translational modification and can also induce the upregulation of autophagy, thus reducing the level of acetyl coenzyme A (AcCoA). In addition, the effect of caloric restriction (CR) on cancer-related chronic inflammation is of great significance in aging. In line with this, SIRT1 protein levels are expanded in response to calorie restriction mimetics (CRM), in this way acting as autophagy inducers relevant to cancer prevention.

引用

页码：1649 / 1656

页数：8

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