Adrenocortical development and cancer: focus on SF-1

被引：42

作者：

Lalli, Enzo ^{[1
,2
]}

机构：

[1] CNRS, UMR 6097, Inst Pharmacol Mol & Cellulaire, F-06560 Valbonne, France

[2] Univ Nice, F-06560 Valbonne, France

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2010年 / 44卷 / 06期

关键词：

STEROIDOGENIC FACTOR-I; NUCLEAR RECEPTOR; ADRENAL DEVELOPMENT; EXPRESSION PROFILES; CELL-PROLIFERATION; GONADAL DEVELOPMENT; SUMO MODIFICATION; INVERSE AGONISTS; HORMONE-RECEPTOR; KNOCKOUT MICE;

D O I：

10.1677/JME-09-0143

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice. Journal of Molecular Endocrinology (2010) 44, 301-307

引用

页码：301 / 307

页数：7

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