Synthesis of 4-benzidinyl butyric acid: A key intermediate for antibodies production against benzidin

被引：5

作者：

Fischer-Durand, N ^{[1
]}

Rejeb, SB ^{[1
]}

Le Goffic, F ^{[1
]}

机构：

[1] ENSCP, CNRS, Lab Bioorgan & Biotechnol, F-75231 Paris 05, France

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 06期

关键词：

D O I：

10.1080/00397919808003065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

a four-step synthesis of monoalkylated benzidin is reported for immunogen preparation against benzidin dye. Use of 10% H2SO4/dioxan for N- Boc cleavage avoids the cyclisation of 4-benzidinyl butyric acid into the corresponding lactam observed with the classical TFA/CH2Cl2 system.

引用

页码：963 / 970

页数：8

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