Fluconazole decreases cyclosporine dosage in renal transplanted dogs

被引：14

作者：

Katayama, Masaaki ^{[1
,2
]}

Igarashi, Hiroyuki ^{[1
]}

Fukai, Kazuhiro ^{[1
]}

Tani, Kenji ^{[3
]}

Momota, Yutaka ^{[4
]}

Kamishina, Hiroaki ^{[5
]}

Tagawa, Masahiro ^{[2
]}

机构：

[1] Iwate Univ, Fac Agr, Dept Vet Med, Div Small Anim Surg, Morioka, Iwate 0208550, Japan

[2] Nippon Vet & Life Sci Univ, Dept Vet Med, Div Vet Surg, Tokyo 1808602, Japan

[3] Yamaguchi Univ, Div Vet Surg, Dept Vet Med, Fac Agr, Yamaguchi 7538515, Japan

[4] Nippon Vet & Life Sci Univ, Dept Vet Nursing & Technol, Tokyo 1808602, Japan

[5] Iwate Univ, Fac Agr, Dept Vet Med, Div Small Anim Internal Med, Morioka, Iwate 0208550, Japan

来源：

RESEARCH IN VETERINARY SCIENCE | 2010年 / 89卷 / 01期

关键词：

Cyclosporine; Fluconazole; Dog; Renal transplantation; Immunosuppressive therapy; PHARMACOKINETICS; KETOCONAZOLE;

D O I：

10.1016/j.rvsc.2009.12.018

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effect of fluconazole (Fez) on the cyclosporine (CsA) dosage was investigated in renal transplanted dogs receiving CsA-based immunosuppressive therapy. Initially, CsA was administered orally twice daily to raise the blood trough level between 400 and 600 ng/ml. After the addition of Fez, the CsA dosage was adjusted to maintain its therapeutic blood concentration. Fcz significantly decreased CsA dosage in both normal and renal transplanted dogs, but a higher dosage of CsA was needed in renal transplanted dogs. In conclusion, Fcz decreases required CsA dosage and thereby reduces the cost of immunosuppressive therapy in canine renal transplantation. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：124 / 125

页数：2

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