Progress in the study of molecular mechanism maintaining embryonic stem cells self-renewal

被引：0
作者：
Jiang, ZY
Yuan, YJ
Ming, ZH
Zhang, M [1 ]
机构：
[1] Zhejiang Univ, Coll Life Sci, Hangzhou 310012, Peoples R China
[2] Tianshui Normal Univ, Coll Life Sci & Chem, Tianshui 741000, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2004年 / 31卷 / 11期
关键词：
embryonic stem cell; self-renewal; signal network; molecular mechanism;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Some intrinsic ESC-specific markers, cytokines and extracelluar matrix in the microenvironment compose of a complex network to co-regulate ESC self-renewal. The molecular mechanism of signal network maintaining ESC self-renewal was investigated by studying the ESC-specific markers, such as Oct-4 and Nonog recently. Moreover, ESC signal pathways, just like LIF-STAT3, Wnt-beta-catenin and BMP-Id, were further deeply studied. In conclusion, the most important key to maintain ESC self-renewal is the balance among the content of various cytokines, extracelluar matrix, and expressing quantity of intrinsic ESC-specific markers by different signal stimulators.
引用
收藏
页码：965 / 968
页数：4
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