Myricetin: targeting signaling networks in cancer and its implication in chemotherapy

被引：69

作者：

Javed, Zeeshan ^{[1
]}

Khan, Khushbukhat ^{[2
]}

Herrera-Bravo, Jesus ^{[3
,4
]}

Naeem, Sajid ^{[5
]}

Iqbal, Muhammad Javed ^{[6
]}

Raza, Qamar ^{[7
]}

Sadia, Haleema ^{[8
]}

Raza, Shahid ^{[1
]}

Bhinder, Munir ^{[9
]}

Calina, Daniela ^{[10
]}

Sharifi-Rad, Javad ^{[11
]}

Cho, William C. ^{[12
]}

机构：

[1] Lahore Garrison Univ, Off Res Innovat & Commercializat, Lahore, Pakistan

[2] Natl Univ Sci & Technol, Atta Ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Sect H12, Islamabad 44000, Pakistan

[3] Univ Santo Tomas, Fac Ciencias, Dept Ciencias Basicas, Santiago, Chile

[4] Univ La Frontera, Ctr Mol Biol & Pharmacogenet, Sci & Technol Bioresource Nucleus, Temuco 4811230, Chile

[5] Lanzhou Univ, Sch Life Sci, Gansu Key Lab Biomonitoring & Bioremediat Environ, Lanzhou 730000, Peoples R China

[6] Univ Sialkot, Fac Sci, Dept Biotechnol, Sialkot, Pakistan

[7] Univ Vet & Anim Sci, Inst Biochem & Biotechnol, Lahore, Punjab, Pakistan

[8] Balochistan Univ Informat Technol Engn & Manageme, Dept Biotechnol, Quetta 87100, Pakistan

[9] Univ Hlth Sci, Dept Human Genet & Mol Biol, Lahore 54600, Pakistan

[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania

[11] Univ Azuay, Fac Med, Cuenca, Ecuador

[12] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2022年 / 22卷 / 01期

关键词：

Myricetin; Cancer; Signaling networks; Apoptosis; Cell cycle; Nano-delivery; DIETARY FLAVONOID INTAKE; IN-VITRO; CELL-DEATH; INHIBITS PROLIFERATION; PROSTATE-CANCER; LUNG-CANCER; HEPG2; CELLS; APOPTOSIS; EXPRESSION; PATHWAY;

D O I：

10.1186/s12935-022-02663-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.

引用

页数：13

共 128 条

[41] Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis [J].

Kang, Nam Joo ;

Jung, Sung Keun ;

Lee, Ki Won ;

Lee, Hyong Joo .

NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER, 2011, 1229 :124-132

[42]

Kim GD, 2017, J CANCER PREV, V22, P219, DOI 10.15430/JCP.2017.22.4.219

[43] Enhancing effects of myricetin on the osteogenic differentiation of human periodontal ligament stem cells via BMP-2/Smad and ERK/JNK/p38 mitogen-activated protein kinase signaling pathway [J].

Kim, Hyang-Yu ;

Park, Sun-Young ;

Choung, Se-Young .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 834 :84-91

[44] MKK4 is a novel target for the inhibition of tumor necrosis factor-α-induced vascular endothelial growth factor expression by myricetin [J].

Kim, Jong-Eun ;

Kwon, Jung Yeon ;

Lee, Dong Eun ;

Kang, Nam Joo ;

Heo, Yong-Seok ;

Lee, Ki Won ;

Lee, Hyong Joo .

BIOCHEMICAL PHARMACOLOGY, 2009, 77 (03) :412-421

[45]

Kim ME, 2014, ANTICANCER RES, V34, P701

[46] Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide [J].

Knickle, Allison ;

Fernando, Wasundara ;

Greenshields, Anna L. ;

Rupasinghe, H. P. Vasantha ;

Hoskin, David W. .

FOOD AND CHEMICAL TOXICOLOGY, 2018, 118 :154-167

[47] Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells [J].

Ko, Seon-Yle .

ARCHIVES OF ORAL BIOLOGY, 2012, 57 (12) :1623-1632

[48] Myricetin directly targets JAK1 to inhibit cell transformation [J].

Kumamoto, Takuma ;

Fujii, Makoto ;

Hou, De-Xing .

CANCER LETTERS, 2009, 275 (01) :17-26

[49] Akt is a direct target for myricetin to inhibit cell transformation [J].

Kumamoto, Takuma ;

Fujii, Makoto ;

Hou, De-Xing .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2009, 332 (1-2) :33-41

[50] Design, in silico modelling and functionality theory of folate-receptor-targeted myricetin-loaded bovine serum albumin nanoparticle formulation for cancer treatment [J].

Kunjiappan, Selvaraj ;

Govindaraj, Saravanan ;

Parasuraman, Pavadai ;

Sankaranarayanan, Murugesan ;

Arunachalam, Sankarganesh ;

Palanisamy, Ponnusamy ;

Mohan, Uma Priya ;

Babkiewicz, Ewa ;

Maszczyk, Piotr ;

Vellaisamy, Sivakumar ;

Panneerselvam, Theivendren .

NANOTECHNOLOGY, 2020, 31 (15)

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