Near-infrared induced phaseshifted ICG/Fe3O4 loaded PLGA nanoparticles for photothermal tumor ablation

被引：48

作者：

Niu, Chengcheng ^{[1
]}

Xu, Yan ^{[1
]}

An, Senbo ^{[2
]}

Zhang, Ming ^{[1
]}

Hu, Yihe ^{[2
]}

Wang, Long ^{[2
]}

Peng, Qinghai ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, Changsha 410011, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha 410008, Hunan, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

COPPER SULFIDE NANOPARTICLES; INDOCYANINE-GREEN; GOLD NANORODS; PERFLUOROCARBON DROPLETS; CARBON NANOTUBES; DELIVERY-SYSTEM; THERAPY; MICROBUBBLES; VAPORIZATION; MICROCAPSULES;

D O I：

10.1038/s41598-017-06122-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Near-infrared (NIR) laser-induced photothermal therapy (PTT) uses a photothermal agent to convert optical energy into thermal energy and has great potential as an effective local, minimally invasive treatment modality for killing cancer cells. To improve the efficacy of PTT, we developed poly(lactideco-glycolide) (PLGA) nanoparticles (NPs) encapsulating superparamagnetic iron oxide (Fe3O4), indocyanine green (ICG), and perfluoropentane (PFP) as synergistic agents for NIR laser-induced PTT. We fabricated a novel type of phase-shifting fluorescent magnetic NPs, Fe3O4/ICG@PLGA/PFP NPs, that effectively produce heat in response to NIR laser irradiation for an enhanced thermal ablation effect and a phase-shift thermoelastic expansion effect, and thus, can be used as a photothermal agent. After in vitro treatment of MCF-7 breast cancer cells with Fe3O4/ICG@PLGA/PFP NPs and NIR laser irradiation, histology and electron microscopy confirmed severe damage to the cells and the formation of many microbubbles with iron particles at the edge or outside of the microbubbles. In vivo experiments in mice with MCF-7 tumors demonstrated that Fe3O4/ICG@PLGA/PFP NPs could achieve tumor ablation upon NIR laser irradiation with minimal toxicity to non-irradiated tissues. Together, our results indicate that Fe3O4/ICG@PLGA/PFP NPs can be used as effective nanotheranostic agents for tumor ablation.

引用

页数：10