Checkpoint inhibition: NK cells enter the scene

被引：19

作者：

Stojanovic, Ana ^{[1
]}

Cerwenka, Adelheid ^{[1
,2
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Ctr Biomed & Med Technol, Mannheim, Germany

[2] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci, Mannheim, Germany

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 07期

关键词：

CANCER-IMMUNOTHERAPY; TIGIT;

D O I：

10.1038/s41590-018-0142-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-associated natural killer cells have elevated expression of the checkpoint inhibitory receptor TIGIT. Monoclonal antibody-mediated blockade targeting TIGIT unleashes the anti-tumor activity of both natural killer cells and T cells in preclinical mouse models and efficiently delays tumor growth.

引用

页码：650 / 652

页数：4

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